TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers

TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers

Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether p...

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Autores principales: Fumie Nakasuka, Sho Tabata, Takeharu Sakamoto, Akiyoshi Hirayama, Hiromichi Ebi, Tadaaki Yamada, Ko Umetsu, Maki Ohishi, Ayano Ueno, Hisatsugu Goto, Masahiro Sugimoto, Yasuhiko Nishioka, Yasuhiro Yamada, Masaru Tomita, Atsuo T. Sasaki, Seiji Yano, Tomoyoshi Soga
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/27b7bb0504c0470a858988500d6af32e
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spelling oai:doaj.org-article:27b7bb0504c0470a858988500d6af32e2021-12-02T17:12:21ZTGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers10.1038/s42003-021-02323-72399-3642https://doaj.org/article/27b7bb0504c0470a858988500d6af32e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02323-7https://doaj.org/toc/2399-3642Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether providing insights into potential mechanisms of metastasis.Fumie NakasukaSho TabataTakeharu SakamotoAkiyoshi HirayamaHiromichi EbiTadaaki YamadaKo UmetsuMaki OhishiAyano UenoHisatsugu GotoMasahiro SugimotoYasuhiko NishiokaYasuhiro YamadaMasaru TomitaAtsuo T. SasakiSeiji YanoTomoyoshi SogaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Fumie Nakasuka
Sho Tabata
Takeharu Sakamoto
Akiyoshi Hirayama
Hiromichi Ebi
Tadaaki Yamada
Ko Umetsu
Maki Ohishi
Ayano Ueno
Hisatsugu Goto
Masahiro Sugimoto
Yasuhiko Nishioka
Yasuhiro Yamada
Masaru Tomita
Atsuo T. Sasaki
Seiji Yano
Tomoyoshi Soga
TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
description Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-β-induced epithelial–mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether providing insights into potential mechanisms of metastasis.
format article
author Fumie Nakasuka
Sho Tabata
Takeharu Sakamoto
Akiyoshi Hirayama
Hiromichi Ebi
Tadaaki Yamada
Ko Umetsu
Maki Ohishi
Ayano Ueno
Hisatsugu Goto
Masahiro Sugimoto
Yasuhiko Nishioka
Yasuhiro Yamada
Masaru Tomita
Atsuo T. Sasaki
Seiji Yano
Tomoyoshi Soga
author_facet Fumie Nakasuka
Sho Tabata
Takeharu Sakamoto
Akiyoshi Hirayama
Hiromichi Ebi
Tadaaki Yamada
Ko Umetsu
Maki Ohishi
Ayano Ueno
Hisatsugu Goto
Masahiro Sugimoto
Yasuhiko Nishioka
Yasuhiro Yamada
Masaru Tomita
Atsuo T. Sasaki
Seiji Yano
Tomoyoshi Soga
author_sort Fumie Nakasuka
title TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
title_short TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
title_full TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
title_fullStr TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
title_full_unstemmed TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
title_sort tgf-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/27b7bb0504c0470a858988500d6af32e
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