Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility

Centrosomes function in cell migration by organizing microtubules. Here, Luo et al. surprisingly show that centrosome proteins also control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusive activity relevant to aggressive cancer motility.

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Autores principales:	Yi Luo, Miriam Barrios-Rodiles, Gagan D. Gupta, Ying Y. Zhang, Abiodun A. Ogunjimi, Mikhail Bashkurov, Johnny M. Tkach, Ainsley Q. Underhill, Liang Zhang, Mohamed Bourmoum, Jeffrey L. Wrana, Laurence Pelletier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27bacde2ea6a46fba858d213b47a28a9
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spelling	oai:doaj.org-article:27bacde2ea6a46fba858d213b47a28a92021-12-02T16:57:31ZAtypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility10.1038/s41467-019-10241-w2041-1723https://doaj.org/article/27bacde2ea6a46fba858d213b47a28a92019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10241-whttps://doaj.org/toc/2041-1723Centrosomes function in cell migration by organizing microtubules. Here, Luo et al. surprisingly show that centrosome proteins also control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusive activity relevant to aggressive cancer motility.Yi LuoMiriam Barrios-RodilesGagan D. GuptaYing Y. ZhangAbiodun A. OgunjimiMikhail BashkurovJohnny M. TkachAinsley Q. UnderhillLiang ZhangMohamed BourmoumJeffrey L. WranaLaurence PelletierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Luo Miriam Barrios-Rodiles Gagan D. Gupta Ying Y. Zhang Abiodun A. Ogunjimi Mikhail Bashkurov Johnny M. Tkach Ainsley Q. Underhill Liang Zhang Mohamed Bourmoum Jeffrey L. Wrana Laurence Pelletier Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
description	Centrosomes function in cell migration by organizing microtubules. Here, Luo et al. surprisingly show that centrosome proteins also control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusive activity relevant to aggressive cancer motility.
format	article
author	Yi Luo Miriam Barrios-Rodiles Gagan D. Gupta Ying Y. Zhang Abiodun A. Ogunjimi Mikhail Bashkurov Johnny M. Tkach Ainsley Q. Underhill Liang Zhang Mohamed Bourmoum Jeffrey L. Wrana Laurence Pelletier
author_facet	Yi Luo Miriam Barrios-Rodiles Gagan D. Gupta Ying Y. Zhang Abiodun A. Ogunjimi Mikhail Bashkurov Johnny M. Tkach Ainsley Q. Underhill Liang Zhang Mohamed Bourmoum Jeffrey L. Wrana Laurence Pelletier
author_sort	Yi Luo
title	Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
title_short	Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
title_full	Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
title_fullStr	Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
title_full_unstemmed	Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
title_sort	atypical function of a centrosomal module in wnt signalling drives contextual cancer cell motility
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/27bacde2ea6a46fba858d213b47a28a9
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Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility

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