Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
Centrosomes function in cell migration by organizing microtubules. Here, Luo et al. surprisingly show that centrosome proteins also control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusive activity relevant to aggressive cancer motility.
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Autores principales: | Yi Luo, Miriam Barrios-Rodiles, Gagan D. Gupta, Ying Y. Zhang, Abiodun A. Ogunjimi, Mikhail Bashkurov, Johnny M. Tkach, Ainsley Q. Underhill, Liang Zhang, Mohamed Bourmoum, Jeffrey L. Wrana, Laurence Pelletier |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/27bacde2ea6a46fba858d213b47a28a9 |
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