Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.

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Autores principales: Ilya G. Serebriiskii, Caitlin Connelly, Garrett Frampton, Justin Newberg, Matthew Cooke, Vince Miller, Siraj Ali, Jeffrey S. Ross, Elizabeth Handorf, Sanjeevani Arora, Christopher Lieu, Erica A. Golemis, Joshua E. Meyer
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee
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spelling oai:doaj.org-article:27bc5c9b4b90416a81f526fbc7b0c8ee2021-12-02T14:35:49ZComprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients10.1038/s41467-019-11530-02041-1723https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11530-0https://doaj.org/toc/2041-1723Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.Ilya G. SerebriiskiiCaitlin ConnellyGarrett FramptonJustin NewbergMatthew CookeVince MillerSiraj AliJeffrey S. RossElizabeth HandorfSanjeevani AroraChristopher LieuErica A. GolemisJoshua E. MeyerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ilya G. Serebriiskii
Caitlin Connelly
Garrett Frampton
Justin Newberg
Matthew Cooke
Vince Miller
Siraj Ali
Jeffrey S. Ross
Elizabeth Handorf
Sanjeevani Arora
Christopher Lieu
Erica A. Golemis
Joshua E. Meyer
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
description Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.
format article
author Ilya G. Serebriiskii
Caitlin Connelly
Garrett Frampton
Justin Newberg
Matthew Cooke
Vince Miller
Siraj Ali
Jeffrey S. Ross
Elizabeth Handorf
Sanjeevani Arora
Christopher Lieu
Erica A. Golemis
Joshua E. Meyer
author_facet Ilya G. Serebriiskii
Caitlin Connelly
Garrett Frampton
Justin Newberg
Matthew Cooke
Vince Miller
Siraj Ali
Jeffrey S. Ross
Elizabeth Handorf
Sanjeevani Arora
Christopher Lieu
Erica A. Golemis
Joshua E. Meyer
author_sort Ilya G. Serebriiskii
title Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_short Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_full Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_fullStr Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_full_unstemmed Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_sort comprehensive characterization of ras mutations in colon and rectal cancers in old and young patients
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee
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