Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.
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Nature Portfolio
2019
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oai:doaj.org-article:27bc5c9b4b90416a81f526fbc7b0c8ee2021-12-02T14:35:49ZComprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients10.1038/s41467-019-11530-02041-1723https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11530-0https://doaj.org/toc/2041-1723Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.Ilya G. SerebriiskiiCaitlin ConnellyGarrett FramptonJustin NewbergMatthew CookeVince MillerSiraj AliJeffrey S. RossElizabeth HandorfSanjeevani AroraChristopher LieuErica A. GolemisJoshua E. MeyerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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Science Q |
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Science Q Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients |
description |
Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability. |
format |
article |
author |
Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer |
author_facet |
Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer |
author_sort |
Ilya G. Serebriiskii |
title |
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients |
title_short |
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients |
title_full |
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients |
title_fullStr |
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients |
title_full_unstemmed |
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients |
title_sort |
comprehensive characterization of ras mutations in colon and rectal cancers in old and young patients |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee |
work_keys_str_mv |
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