Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.

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Autores principales:	Ilya G. Serebriiskii, Caitlin Connelly, Garrett Frampton, Justin Newberg, Matthew Cooke, Vince Miller, Siraj Ali, Jeffrey S. Ross, Elizabeth Handorf, Sanjeevani Arora, Christopher Lieu, Erica A. Golemis, Joshua E. Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee
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spelling	oai:doaj.org-article:27bc5c9b4b90416a81f526fbc7b0c8ee2021-12-02T14:35:49ZComprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients10.1038/s41467-019-11530-02041-1723https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11530-0https://doaj.org/toc/2041-1723Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.Ilya G. SerebriiskiiCaitlin ConnellyGarrett FramptonJustin NewbergMatthew CookeVince MillerSiraj AliJeffrey S. RossElizabeth HandorfSanjeevani AroraChristopher LieuErica A. GolemisJoshua E. MeyerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
description	Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.
format	article
author	Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer
author_facet	Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer
author_sort	Ilya G. Serebriiskii
title	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_short	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_full	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_fullStr	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_full_unstemmed	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_sort	comprehensive characterization of ras mutations in colon and rectal cancers in old and young patients
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/27bc5c9b4b90416a81f526fbc7b0c8ee
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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

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