Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol

Abstract Introduction- Now a day’s colorectal cancer (CRC) is one of the most deadly cancers in the world. The objective of this investigation was to evaluate the protective effect of gallic acid and pyrogallol in colorectal cancer. Previous reports suggest that there is an association present betwe...

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Autores principales:	Debanjan Mitra, Anumita Dey, Ishita Biswas, Pradeep Das Mohapatra
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	colorectal cancer descriptor properties molecular docking binding energy Medicine R
Acceso en línea:	https://doaj.org/article/27bc9541dfa84582b575c4957aa5f52e
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spelling	oai:doaj.org-article:27bc9541dfa84582b575c4957aa5f52e2021-11-14T06:50:29ZBioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol2783-243010.30476/acrr.2021.89642.1080https://doaj.org/article/27bc9541dfa84582b575c4957aa5f52e2021-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47450_224f0bde28b2fefd56816886d6dc4b96.pdfhttps://doaj.org/toc/2783-2430Abstract Introduction- Now a day’s colorectal cancer (CRC) is one of the most deadly cancers in the world. The objective of this investigation was to evaluate the protective effect of gallic acid and pyrogallol in colorectal cancer. Previous reports suggest that there is an association present between some tannase producing bacteria and colorectal cancer. Tannase hydrolyze tannic acid into gallic acid and pyrogallol. Are those compounds have any therapeutic effect on colorectal cancer? This study will help to find those quarries. Methods-The remedial effect of gallic acid and pyrogallol was studied by descriptor properties and molecular docking methods. 100 CRC causing protein structures were docked in this investigation. Results- Lipinski Rule of Five and other descriptor properties of those compounds have showed their nontoxic and therapeutic nature. Molecular docking studies have showed highest score -38.22 KJ/Mol with gallic acid and -33.6 KJ/Mol with pyrogallol. Conclusion- This is the first report on docking investigation of these large numbers of protein. The findings of this research concluded that gallic acid and pyrogallol have a protective effect in colorectal cancer by stopping the effect of those CRC causing protein.Debanjan MitraAnumita DeyIshita BiswasPradeep Das MohapatraShiraz University of Medical Sciencesarticlecolorectal cancerdescriptor propertiesmolecular dockingbinding energyMedicineRENIranian Journal of Colorectal Research, Vol 9, Iss 1, Pp 32-39 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer descriptor properties molecular docking binding energy Medicine R
spellingShingle	colorectal cancer descriptor properties molecular docking binding energy Medicine R Debanjan Mitra Anumita Dey Ishita Biswas Pradeep Das Mohapatra Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
description	Abstract Introduction- Now a day’s colorectal cancer (CRC) is one of the most deadly cancers in the world. The objective of this investigation was to evaluate the protective effect of gallic acid and pyrogallol in colorectal cancer. Previous reports suggest that there is an association present between some tannase producing bacteria and colorectal cancer. Tannase hydrolyze tannic acid into gallic acid and pyrogallol. Are those compounds have any therapeutic effect on colorectal cancer? This study will help to find those quarries. Methods-The remedial effect of gallic acid and pyrogallol was studied by descriptor properties and molecular docking methods. 100 CRC causing protein structures were docked in this investigation. Results- Lipinski Rule of Five and other descriptor properties of those compounds have showed their nontoxic and therapeutic nature. Molecular docking studies have showed highest score -38.22 KJ/Mol with gallic acid and -33.6 KJ/Mol with pyrogallol. Conclusion- This is the first report on docking investigation of these large numbers of protein. The findings of this research concluded that gallic acid and pyrogallol have a protective effect in colorectal cancer by stopping the effect of those CRC causing protein.
format	article
author	Debanjan Mitra Anumita Dey Ishita Biswas Pradeep Das Mohapatra
author_facet	Debanjan Mitra Anumita Dey Ishita Biswas Pradeep Das Mohapatra
author_sort	Debanjan Mitra
title	Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
title_short	Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
title_full	Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
title_fullStr	Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
title_full_unstemmed	Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol
title_sort	bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of gallic acid and pyrogallol
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/27bc9541dfa84582b575c4957aa5f52e
work_keys_str_mv	AT debanjanmitra bioactivecompoundsasapotentialinhibitorofcolorectalcanceraninsilicostudyofgallicacidandpyrogallol AT anumitadey bioactivecompoundsasapotentialinhibitorofcolorectalcanceraninsilicostudyofgallicacidandpyrogallol AT ishitabiswas bioactivecompoundsasapotentialinhibitorofcolorectalcanceraninsilicostudyofgallicacidandpyrogallol AT pradeepdasmohapatra bioactivecompoundsasapotentialinhibitorofcolorectalcanceraninsilicostudyofgallicacidandpyrogallol
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Bioactive compounds as a potential inhibitor of colorectal cancer; an insilico study of Gallic acid and Pyrogallol

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