Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort

Abstract The present study investigated the effects of acute melatonin administration on the biomarkers of energy substrates, GLUT4, and FAT/CD36 of skeletal muscle and its performance in rats subjected to exhaustive swimming exercise at an intensity corresponding to the maximal aerobic capacity (tl...

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Autores principales:	Vinícius Silva Faria, Taciane Maria Melges Pejon, Claudio Alexandre Gobatto, Gustavo Gomes de Araujo, Anabelle Silva Cornachione, Wladimir Rafael Beck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27be7c1068a446ffb66a3d9a54bc7e03
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spelling	oai:doaj.org-article:27be7c1068a446ffb66a3d9a54bc7e032021-12-02T17:17:39ZAcute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort10.1038/s41598-021-97364-72045-2322https://doaj.org/article/27be7c1068a446ffb66a3d9a54bc7e032021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97364-7https://doaj.org/toc/2045-2322Abstract The present study investigated the effects of acute melatonin administration on the biomarkers of energy substrates, GLUT4, and FAT/CD36 of skeletal muscle and its performance in rats subjected to exhaustive swimming exercise at an intensity corresponding to the maximal aerobic capacity (tlim). The incremental test was performed to individually determine the exercise intensity prescription and 48 h after, the animals received melatonin (10 mg·kg−1) or vehicles 30 min prior to tlim. Afterwards, the animals were euthanized 1 or 3 h after the exhaustion for blood and muscles storage. The experiment 1 found that melatonin increased the content of glycogen and GLUT4 in skeletal muscles of the animals that were euthanized 1 (p < 0.05; 22.33% and 41.87%) and 3 h (p < 0.05; 37.62% and 57.87%) after the last procedures. In experiment 2, melatonin enhanced the tlim (p = 0.01; 49.42%), the glycogen content (p < 0.05; 40.03%), GLUT4 and FAT/CD36 in exercised skeletal muscles (F = 26.83 and F = 25.28, p < 0.01). In summary, melatonin increased energy substrate availability prior to exercise, improved the exercise tolerance, and accelerated the recovery of muscle energy substrates after the tlim, possibly through GLUT4 and FAT/CD36.Vinícius Silva FariaTaciane Maria Melges PejonClaudio Alexandre GobattoGustavo Gomes de AraujoAnabelle Silva CornachioneWladimir Rafael BeckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vinícius Silva Faria Taciane Maria Melges Pejon Claudio Alexandre Gobatto Gustavo Gomes de Araujo Anabelle Silva Cornachione Wladimir Rafael Beck Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
description	Abstract The present study investigated the effects of acute melatonin administration on the biomarkers of energy substrates, GLUT4, and FAT/CD36 of skeletal muscle and its performance in rats subjected to exhaustive swimming exercise at an intensity corresponding to the maximal aerobic capacity (tlim). The incremental test was performed to individually determine the exercise intensity prescription and 48 h after, the animals received melatonin (10 mg·kg−1) or vehicles 30 min prior to tlim. Afterwards, the animals were euthanized 1 or 3 h after the exhaustion for blood and muscles storage. The experiment 1 found that melatonin increased the content of glycogen and GLUT4 in skeletal muscles of the animals that were euthanized 1 (p < 0.05; 22.33% and 41.87%) and 3 h (p < 0.05; 37.62% and 57.87%) after the last procedures. In experiment 2, melatonin enhanced the tlim (p = 0.01; 49.42%), the glycogen content (p < 0.05; 40.03%), GLUT4 and FAT/CD36 in exercised skeletal muscles (F = 26.83 and F = 25.28, p < 0.01). In summary, melatonin increased energy substrate availability prior to exercise, improved the exercise tolerance, and accelerated the recovery of muscle energy substrates after the tlim, possibly through GLUT4 and FAT/CD36.
format	article
author	Vinícius Silva Faria Taciane Maria Melges Pejon Claudio Alexandre Gobatto Gustavo Gomes de Araujo Anabelle Silva Cornachione Wladimir Rafael Beck
author_facet	Vinícius Silva Faria Taciane Maria Melges Pejon Claudio Alexandre Gobatto Gustavo Gomes de Araujo Anabelle Silva Cornachione Wladimir Rafael Beck
author_sort	Vinícius Silva Faria
title	Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
title_short	Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
title_full	Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
title_fullStr	Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
title_full_unstemmed	Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
title_sort	acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27be7c1068a446ffb66a3d9a54bc7e03
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Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort

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