Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes

Aim. To study the quantity of endothelial progenitor cells (EPCs) and levels of vascular endothelial growth factor A (VEGF-A) in patients with type 2 diabetes mellitus (T2DM) after endovascular interventions on coronary and peripheral arteries. Materials and methods. We observed 68 patients with st...

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Autores principales: Marina Sergeevna Michurova, Victor Yurievich Kalashnikov, Olga Michailovna Smirnova, Sergey Anatol'evich Terekhin, Olga Nikolaevna Ivanova, Svetlana Michailovna Stepanova, Aleksandr Victorovich Ilin, Ivan Ivanovich Dedov
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Publicado: Endocrinology Research Centre 2017
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spelling oai:doaj.org-article:27bea696ccbe4ab4bec869c7f0ffb18f2021-11-14T09:00:21ZEndothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes2072-03512072-037810.14341/DM8173https://doaj.org/article/27bea696ccbe4ab4bec869c7f0ffb18f2017-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8173https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study the quantity of endothelial progenitor cells (EPCs) and levels of vascular endothelial growth factor A (VEGF-A) in patients with type 2 diabetes mellitus (T2DM) after endovascular interventions on coronary and peripheral arteries. Materials and methods. We observed 68 patients with stable angina pectoris and critical limb ischaemia, admitted for elective percutaneous coronary intervention and endovascular revascularisation of the lower extremity. The number of CD34+VEGFR2+CD45- and CD34+CD133+CD45- cells and levels of VEGF-A were determined before endovascular intervention and 2–4 days after the surgery. Results. We found that in patients without diabetes, the levels of EPCs increased significantly after endovascular interventions (CD34+VEGFR2+CD45-cells, p < 0.0001; CD34+ CD133+CD45-cells p = 0.041). The levels of EPCs in the peripheral blood of patients with T2DM before and after endovascular interventions did not significantly differ. The analysis of VEGF-A showed a statistically significant increase after intervention in both groups. In addition, in patients with an HbA1c level of <8% and duration of diabetes of <10 years, the levels of EPCs significantly increased (p = 0.001 and 0.005, respectively). In patients with an HbA1c level of ≥8% and duration of diabetes of >10 years, the levels of EPCs before and after endovascular interventions did not significantly differ. Conclusions. Patients with diabetes exhibited impaired EPC mobilisation after endovascular interventions. Poor glycaemic control and a long duration of diabetes are among the risk factors of EPC mobilisation.Marina Sergeevna MichurovaVictor Yurievich KalashnikovOlga Michailovna SmirnovaSergey Anatol'evich TerekhinOlga Nikolaevna IvanovaSvetlana Michailovna StepanovaAleksandr Victorovich IlinIvan Ivanovich DedovEndocrinology Research Centrearticlediabetesendothelial progenitor cellscoronary heart diseasecritical limb ischemiapercutaneous coronary interventionlower extremity revascularizationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 1, Pp 59-67 (2017)
institution DOAJ
collection DOAJ
language EN
RU
topic diabetes
endothelial progenitor cells
coronary heart disease
critical limb ischemia
percutaneous coronary intervention
lower extremity revascularization
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle diabetes
endothelial progenitor cells
coronary heart disease
critical limb ischemia
percutaneous coronary intervention
lower extremity revascularization
Nutritional diseases. Deficiency diseases
RC620-627
Marina Sergeevna Michurova
Victor Yurievich Kalashnikov
Olga Michailovna Smirnova
Sergey Anatol'evich Terekhin
Olga Nikolaevna Ivanova
Svetlana Michailovna Stepanova
Aleksandr Victorovich Ilin
Ivan Ivanovich Dedov
Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
description Aim. To study the quantity of endothelial progenitor cells (EPCs) and levels of vascular endothelial growth factor A (VEGF-A) in patients with type 2 diabetes mellitus (T2DM) after endovascular interventions on coronary and peripheral arteries. Materials and methods. We observed 68 patients with stable angina pectoris and critical limb ischaemia, admitted for elective percutaneous coronary intervention and endovascular revascularisation of the lower extremity. The number of CD34+VEGFR2+CD45- and CD34+CD133+CD45- cells and levels of VEGF-A were determined before endovascular intervention and 2–4 days after the surgery. Results. We found that in patients without diabetes, the levels of EPCs increased significantly after endovascular interventions (CD34+VEGFR2+CD45-cells, p < 0.0001; CD34+ CD133+CD45-cells p = 0.041). The levels of EPCs in the peripheral blood of patients with T2DM before and after endovascular interventions did not significantly differ. The analysis of VEGF-A showed a statistically significant increase after intervention in both groups. In addition, in patients with an HbA1c level of <8% and duration of diabetes of <10 years, the levels of EPCs significantly increased (p = 0.001 and 0.005, respectively). In patients with an HbA1c level of ≥8% and duration of diabetes of >10 years, the levels of EPCs before and after endovascular interventions did not significantly differ. Conclusions. Patients with diabetes exhibited impaired EPC mobilisation after endovascular interventions. Poor glycaemic control and a long duration of diabetes are among the risk factors of EPC mobilisation.
format article
author Marina Sergeevna Michurova
Victor Yurievich Kalashnikov
Olga Michailovna Smirnova
Sergey Anatol'evich Terekhin
Olga Nikolaevna Ivanova
Svetlana Michailovna Stepanova
Aleksandr Victorovich Ilin
Ivan Ivanovich Dedov
author_facet Marina Sergeevna Michurova
Victor Yurievich Kalashnikov
Olga Michailovna Smirnova
Sergey Anatol'evich Terekhin
Olga Nikolaevna Ivanova
Svetlana Michailovna Stepanova
Aleksandr Victorovich Ilin
Ivan Ivanovich Dedov
author_sort Marina Sergeevna Michurova
title Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
title_short Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
title_full Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
title_fullStr Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
title_full_unstemmed Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
title_sort endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes
publisher Endocrinology Research Centre
publishDate 2017
url https://doaj.org/article/27bea696ccbe4ab4bec869c7f0ffb18f
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