Drug and disease signature integration identifies synergistic combinations in glioblastoma

Inherent or acquired resistance to treatment of glioblastoma (GBM) is nearly universal. Here, the authors introduce a platform to identify synergistic drug combinations for patient-specific treatment of GBM based on gene expression signatures and small molecule perturbation-response profiles.

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Autores principales: Vasileios Stathias, Anna M. Jermakowicz, Marie E. Maloof, Michele Forlin, Winston Walters, Robert K. Suter, Michael A. Durante, Sion L. Williams, J. William Harbour, Claude-Henry Volmar, Nicholas J. Lyons, Claes Wahlestedt, Regina M. Graham, Michael E. Ivan, Ricardo J. Komotar, Jann N. Sarkaria, Aravind Subramanian, Todd R. Golub, Stephan C. Schürer, Nagi G. Ayad
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/27c294a5f7c843d6a3a8dc34a08977c6
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spelling oai:doaj.org-article:27c294a5f7c843d6a3a8dc34a08977c62021-12-02T17:32:49ZDrug and disease signature integration identifies synergistic combinations in glioblastoma10.1038/s41467-018-07659-z2041-1723https://doaj.org/article/27c294a5f7c843d6a3a8dc34a08977c62018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07659-zhttps://doaj.org/toc/2041-1723Inherent or acquired resistance to treatment of glioblastoma (GBM) is nearly universal. Here, the authors introduce a platform to identify synergistic drug combinations for patient-specific treatment of GBM based on gene expression signatures and small molecule perturbation-response profiles.Vasileios StathiasAnna M. JermakowiczMarie E. MaloofMichele ForlinWinston WaltersRobert K. SuterMichael A. DuranteSion L. WilliamsJ. William HarbourClaude-Henry VolmarNicholas J. LyonsClaes WahlestedtRegina M. GrahamMichael E. IvanRicardo J. KomotarJann N. SarkariaAravind SubramanianTodd R. GolubStephan C. SchürerNagi G. AyadNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Vasileios Stathias
Anna M. Jermakowicz
Marie E. Maloof
Michele Forlin
Winston Walters
Robert K. Suter
Michael A. Durante
Sion L. Williams
J. William Harbour
Claude-Henry Volmar
Nicholas J. Lyons
Claes Wahlestedt
Regina M. Graham
Michael E. Ivan
Ricardo J. Komotar
Jann N. Sarkaria
Aravind Subramanian
Todd R. Golub
Stephan C. Schürer
Nagi G. Ayad
Drug and disease signature integration identifies synergistic combinations in glioblastoma
description Inherent or acquired resistance to treatment of glioblastoma (GBM) is nearly universal. Here, the authors introduce a platform to identify synergistic drug combinations for patient-specific treatment of GBM based on gene expression signatures and small molecule perturbation-response profiles.
format article
author Vasileios Stathias
Anna M. Jermakowicz
Marie E. Maloof
Michele Forlin
Winston Walters
Robert K. Suter
Michael A. Durante
Sion L. Williams
J. William Harbour
Claude-Henry Volmar
Nicholas J. Lyons
Claes Wahlestedt
Regina M. Graham
Michael E. Ivan
Ricardo J. Komotar
Jann N. Sarkaria
Aravind Subramanian
Todd R. Golub
Stephan C. Schürer
Nagi G. Ayad
author_facet Vasileios Stathias
Anna M. Jermakowicz
Marie E. Maloof
Michele Forlin
Winston Walters
Robert K. Suter
Michael A. Durante
Sion L. Williams
J. William Harbour
Claude-Henry Volmar
Nicholas J. Lyons
Claes Wahlestedt
Regina M. Graham
Michael E. Ivan
Ricardo J. Komotar
Jann N. Sarkaria
Aravind Subramanian
Todd R. Golub
Stephan C. Schürer
Nagi G. Ayad
author_sort Vasileios Stathias
title Drug and disease signature integration identifies synergistic combinations in glioblastoma
title_short Drug and disease signature integration identifies synergistic combinations in glioblastoma
title_full Drug and disease signature integration identifies synergistic combinations in glioblastoma
title_fullStr Drug and disease signature integration identifies synergistic combinations in glioblastoma
title_full_unstemmed Drug and disease signature integration identifies synergistic combinations in glioblastoma
title_sort drug and disease signature integration identifies synergistic combinations in glioblastoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/27c294a5f7c843d6a3a8dc34a08977c6
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