IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS

The article presents the result of the detection of different-level inflammatory factors of immune defense in patients with chronic pyelonephritis (CP) with detection of definite interconnections between these factors and estimation of their significance in the chronification of the process. The abs...

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Autores principales:	V. I. Nikulicheva, G. S. Safuanova, N. S. Karpina, T. Y. Lekhmus, D. R. Vagapova, S. V. Alonova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2014
Materias:	chronic pyelonephritis immunity cytokines adhesive molecule icam-3 Science Q
Acceso en línea:	https://doaj.org/article/27c2c03e526c434db5a5ed076efb4d69
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spelling	oai:doaj.org-article:27c2c03e526c434db5a5ed076efb4d692021-11-23T06:14:30ZIMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS2541-94202587-9596https://doaj.org/article/27c2c03e526c434db5a5ed076efb4d692014-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1712https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the result of the detection of different-level inflammatory factors of immune defense in patients with chronic pyelonephritis (CP) with detection of definite interconnections between these factors and estimation of their significance in the chronification of the process. The absence of adequate effector reaction on the chronic inflammation with considerable (p < 0,05-0,001) depression of the phagocytosis system, decrease of stimulated reaction of blast-transformed lymphocytes, CD4-helpers, CD16-cells, cytotoxic lymphocytes (CD8), B-lymphocytes (CD22) with oppression of especially secondary immune response against the background of visible (p < 0,05-0,001) decrease of contents of activated lymphocytes (CD25), apoptosis receptors (CD95), antigene of main complex of histocompatibility of 11 class HLADR+, adhesive molecules ICAM-3 and proinflammatory cytokines IL-1β, IL-6, IL-8, ФНО-α was determined. The character of determined changes in the contents of immune-inflammatory markers that reflect different levels of immune system functioning points at profound disorders of effector reaction with significant oppression of recognition function and destruction by immune system of both endogenous and exogenous antigens and evident inconsistency of cytokines regulatory system in CP patients.V. I. NikulichevaG. S. SafuanovaN. S. KarpinaT. Y. LekhmusD. R. VagapovaS. V. AlonovaScientific Сentre for Family Health and Human Reproduction Problemsarticlechronic pyelonephritisimmunitycytokinesadhesive molecule icam-3ScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 45-49 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic pyelonephritis immunity cytokines adhesive molecule icam-3 Science Q
spellingShingle	chronic pyelonephritis immunity cytokines adhesive molecule icam-3 Science Q V. I. Nikulicheva G. S. Safuanova N. S. Karpina T. Y. Lekhmus D. R. Vagapova S. V. Alonova IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS
description	The article presents the result of the detection of different-level inflammatory factors of immune defense in patients with chronic pyelonephritis (CP) with detection of definite interconnections between these factors and estimation of their significance in the chronification of the process. The absence of adequate effector reaction on the chronic inflammation with considerable (p < 0,05-0,001) depression of the phagocytosis system, decrease of stimulated reaction of blast-transformed lymphocytes, CD4-helpers, CD16-cells, cytotoxic lymphocytes (CD8), B-lymphocytes (CD22) with oppression of especially secondary immune response against the background of visible (p < 0,05-0,001) decrease of contents of activated lymphocytes (CD25), apoptosis receptors (CD95), antigene of main complex of histocompatibility of 11 class HLADR+, adhesive molecules ICAM-3 and proinflammatory cytokines IL-1β, IL-6, IL-8, ФНО-α was determined. The character of determined changes in the contents of immune-inflammatory markers that reflect different levels of immune system functioning points at profound disorders of effector reaction with significant oppression of recognition function and destruction by immune system of both endogenous and exogenous antigens and evident inconsistency of cytokines regulatory system in CP patients.
format	article
author	V. I. Nikulicheva G. S. Safuanova N. S. Karpina T. Y. Lekhmus D. R. Vagapova S. V. Alonova
author_facet	V. I. Nikulicheva G. S. Safuanova N. S. Karpina T. Y. Lekhmus D. R. Vagapova S. V. Alonova
author_sort	V. I. Nikulicheva
title	IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS
title_short	IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS
title_full	IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS
title_fullStr	IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS
title_full_unstemmed	IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS
title_sort	immune-inflammatory markers of chronic pyelonephritis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2014
url	https://doaj.org/article/27c2c03e526c434db5a5ed076efb4d69
work_keys_str_mv	AT vinikulicheva immuneinflammatorymarkersofchronicpyelonephritis AT gssafuanova immuneinflammatorymarkersofchronicpyelonephritis AT nskarpina immuneinflammatorymarkersofchronicpyelonephritis AT tylekhmus immuneinflammatorymarkersofchronicpyelonephritis AT drvagapova immuneinflammatorymarkersofchronicpyelonephritis AT svalonova immuneinflammatorymarkersofchronicpyelonephritis
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IMMUNE-INFLAMMATORY MARKERS of CHRONIC PYELONEPHRITIS

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