Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.

Guardado en:

Detalles Bibliográficos
Autores principales:	Joonseok Cho, Yujian Zhang, Shi-Young Park, Anna-Maria Joseph, Chul Han, Hyo-Jin Park, Srilaxmi Kalavalapalli, Sung-Kook Chun, Drake Morgan, Jae-Sung Kim, Shinichi Someya, Clayton E. Mathews, Young Jae Lee, Stephanie E. Wohlgemuth, Nishanth E. Sunny, Hui-Young Lee, Cheol Soo Choi, Takayuki Shiratsuchi, S. Paul Oh, Naohiro Terada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27c33827aff94d8b88865b49e3ea384d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:27c33827aff94d8b88865b49e3ea384d
record_format	dspace
spelling	oai:doaj.org-article:27c33827aff94d8b88865b49e3ea384d2021-12-02T15:38:30ZMitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance10.1038/ncomms144772041-1723https://doaj.org/article/27c33827aff94d8b88865b49e3ea384d2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14477https://doaj.org/toc/2041-1723Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.Joonseok ChoYujian ZhangShi-Young ParkAnna-Maria JosephChul HanHyo-Jin ParkSrilaxmi KalavalapalliSung-Kook ChunDrake MorganJae-Sung KimShinichi SomeyaClayton E. MathewsYoung Jae LeeStephanie E. WohlgemuthNishanth E. SunnyHui-Young LeeCheol Soo ChoiTakayuki ShiratsuchiS. Paul OhNaohiro TeradaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joonseok Cho Yujian Zhang Shi-Young Park Anna-Maria Joseph Chul Han Hyo-Jin Park Srilaxmi Kalavalapalli Sung-Kook Chun Drake Morgan Jae-Sung Kim Shinichi Someya Clayton E. Mathews Young Jae Lee Stephanie E. Wohlgemuth Nishanth E. Sunny Hui-Young Lee Cheol Soo Choi Takayuki Shiratsuchi S. Paul Oh Naohiro Terada Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
description	Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.
format	article
author	Joonseok Cho Yujian Zhang Shi-Young Park Anna-Maria Joseph Chul Han Hyo-Jin Park Srilaxmi Kalavalapalli Sung-Kook Chun Drake Morgan Jae-Sung Kim Shinichi Someya Clayton E. Mathews Young Jae Lee Stephanie E. Wohlgemuth Nishanth E. Sunny Hui-Young Lee Cheol Soo Choi Takayuki Shiratsuchi S. Paul Oh Naohiro Terada
author_facet	Joonseok Cho Yujian Zhang Shi-Young Park Anna-Maria Joseph Chul Han Hyo-Jin Park Srilaxmi Kalavalapalli Sung-Kook Chun Drake Morgan Jae-Sung Kim Shinichi Someya Clayton E. Mathews Young Jae Lee Stephanie E. Wohlgemuth Nishanth E. Sunny Hui-Young Lee Cheol Soo Choi Takayuki Shiratsuchi S. Paul Oh Naohiro Terada
author_sort	Joonseok Cho
title	Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
title_short	Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
title_full	Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
title_fullStr	Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
title_full_unstemmed	Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
title_sort	mitochondrial atp transporter depletion protects mice against liver steatosis and insulin resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/27c33827aff94d8b88865b49e3ea384d
work_keys_str_mv	AT joonseokcho mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT yujianzhang mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT shiyoungpark mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT annamariajoseph mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT chulhan mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT hyojinpark mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT srilaxmikalavalapalli mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT sungkookchun mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT drakemorgan mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT jaesungkim mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT shinichisomeya mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT claytonemathews mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT youngjaelee mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT stephanieewohlgemuth mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT nishanthesunny mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT huiyounglee mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT cheolsoochoi mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT takayukishiratsuchi mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT spauloh mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance AT naohiroterada mitochondrialatptransporterdepletionprotectsmiceagainstliversteatosisandinsulinresistance
_version_	1718386161442881536

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Ejemplares similares