The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis

<h4>Introduction</h4> Soil transmitted helminth (STH) infections cause one of the most prevalent diseases in man. STHs disproportionately impact socio-economically disadvantaged communities including minority indigenous populations. This systematic review aimed to quantify the prevalence...

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Autores principales:	Beth Gilmour, Kefyalew Addis Alene, Archie C. A. Clements
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/27c40c5e350540d1a9d45c1c72685145
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id	oai:doaj.org-article:27c40c5e350540d1a9d45c1c72685145
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Beth Gilmour Kefyalew Addis Alene Archie C. A. Clements The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis
description	<h4>Introduction</h4> Soil transmitted helminth (STH) infections cause one of the most prevalent diseases in man. STHs disproportionately impact socio-economically disadvantaged communities including minority indigenous populations. This systematic review aimed to quantify the prevalence of STH infection within minority indigenous populations of the South-East Asia and Western Pacific Regions. <h4>Methods</h4> The systematic review was conducted in accordance with The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines following a published protocol. A random effects meta-analysis was used to estimate the pooled prevalence of STH infection, and meta-regression analysis was used to quantify associations with study characteristics. Where comparative data were available, sub-group analysis was conducted to evaluate the risk of STH infection in minority indigenous people relative to other population groups. The heterogeneity between studies was evaluated visually using Forest plots and was assessed quantitatively by the index of heterogeneity (I2) and Cochran Q-statistics. <h4>Results</h4> From 1,366 unique studies that were identified, 81 were included in the final analysis. The pooled prevalence of infection within minority indigenous populations was 61.4% (95% CI 50.8, 71.4) for overall STH infection; 32.3% (95% CI 25.7, 39.3) for Ascaris.lumbricoides; 43.6% (95% CI 32.6, 54.8) for Trichuris.trichiura; 19.9% (95% CI 15.7, 24.5) for hookworm and 6.3% (95% CI 3.2, 10.2) for Strongyloides.stercoralis. A significant increase in T. trichiura prevalence was observed over time. The stratified analysis showed that the prevalence of infection for STH overall and for each STH species were not significantly different in minority indigenous participants compared to other populations groups. <h4>Conclusion</h4> The prevalence of STH infection is high within minority indigenous populations across countries at very different levels of socio-economic development. The increasing prevalence of T. trichiura calls for the implementation of more effective therapies and control strategies. Author summary Neglected Tropical Diseases (NTD) are caused by a range of infectious pathogens and have their greatest impact on poor and vulnerable populations. One such population group, is indigenous people, who are disproportionately impacted by poverty and social disadvantage. Among the World Health Organization (WHO) list of 20 NTD, soil transmitted helminth (STH; Ascaris lumbricoides, Trichuris trichiura and hookworm) infections are the most prevalent and burdensome. This systematic review and meta-analysis evaluated the prevalence of STH infection in minority indigenous populations of the South-East Asia (SEAR) and Western Pacific Regions (WPR). The results showed a high prevalence of infection for all STH species in minority indigenous populations of both developing and highly industrialized nations. Of concern was the increasing prevalence of T. trichiura infection over time, which calls for the identification and implementation of more effective therapies and control strategies. Where comparative data were available, the review showed infection prevalence of all STH species not to be significantly different in minority indigenous people compared to those of other population groups. To help break the health burden and poverty cycle created by these infections, accurate, relevant data will be required to inform effective and appropriate interventions.
format	article
author	Beth Gilmour Kefyalew Addis Alene Archie C. A. Clements
author_facet	Beth Gilmour Kefyalew Addis Alene Archie C. A. Clements
author_sort	Beth Gilmour
title	The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis
title_short	The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis
title_full	The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis
title_fullStr	The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis
title_full_unstemmed	The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis
title_sort	prevalence of soil transmitted helminth infections in minority indigenous populations of south-east asia and the western pacific region: a systematic review and meta-analysis
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/27c40c5e350540d1a9d45c1c72685145
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spelling	oai:doaj.org-article:27c40c5e350540d1a9d45c1c726851452021-11-18T09:14:49ZThe prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis1935-27271935-2735https://doaj.org/article/27c40c5e350540d1a9d45c1c726851452021-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580241/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Introduction</h4> Soil transmitted helminth (STH) infections cause one of the most prevalent diseases in man. STHs disproportionately impact socio-economically disadvantaged communities including minority indigenous populations. This systematic review aimed to quantify the prevalence of STH infection within minority indigenous populations of the South-East Asia and Western Pacific Regions. <h4>Methods</h4> The systematic review was conducted in accordance with The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines following a published protocol. A random effects meta-analysis was used to estimate the pooled prevalence of STH infection, and meta-regression analysis was used to quantify associations with study characteristics. Where comparative data were available, sub-group analysis was conducted to evaluate the risk of STH infection in minority indigenous people relative to other population groups. The heterogeneity between studies was evaluated visually using Forest plots and was assessed quantitatively by the index of heterogeneity (I2) and Cochran Q-statistics. <h4>Results</h4> From 1,366 unique studies that were identified, 81 were included in the final analysis. The pooled prevalence of infection within minority indigenous populations was 61.4% (95% CI 50.8, 71.4) for overall STH infection; 32.3% (95% CI 25.7, 39.3) for Ascaris.lumbricoides; 43.6% (95% CI 32.6, 54.8) for Trichuris.trichiura; 19.9% (95% CI 15.7, 24.5) for hookworm and 6.3% (95% CI 3.2, 10.2) for Strongyloides.stercoralis. A significant increase in T. trichiura prevalence was observed over time. The stratified analysis showed that the prevalence of infection for STH overall and for each STH species were not significantly different in minority indigenous participants compared to other populations groups. <h4>Conclusion</h4> The prevalence of STH infection is high within minority indigenous populations across countries at very different levels of socio-economic development. The increasing prevalence of T. trichiura calls for the implementation of more effective therapies and control strategies. Author summary Neglected Tropical Diseases (NTD) are caused by a range of infectious pathogens and have their greatest impact on poor and vulnerable populations. One such population group, is indigenous people, who are disproportionately impacted by poverty and social disadvantage. Among the World Health Organization (WHO) list of 20 NTD, soil transmitted helminth (STH; Ascaris lumbricoides, Trichuris trichiura and hookworm) infections are the most prevalent and burdensome. This systematic review and meta-analysis evaluated the prevalence of STH infection in minority indigenous populations of the South-East Asia (SEAR) and Western Pacific Regions (WPR). The results showed a high prevalence of infection for all STH species in minority indigenous populations of both developing and highly industrialized nations. Of concern was the increasing prevalence of T. trichiura infection over time, which calls for the identification and implementation of more effective therapies and control strategies. Where comparative data were available, the review showed infection prevalence of all STH species not to be significantly different in minority indigenous people compared to those of other population groups. To help break the health burden and poverty cycle created by these infections, accurate, relevant data will be required to inform effective and appropriate interventions.Beth GilmourKefyalew Addis AleneArchie C. A. ClementsPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)

The prevalence of soil transmitted helminth infections in minority indigenous populations of South-East Asia and the Western Pacific Region: A systematic review and meta-analysis

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