Optical control of protein phosphatase function
Protein phosphatases play an essential role in signal transduction, but are understudied due to the difficulties in detecting phosphate removal and the lack of good inhibitors. Here the authors develop a light-activated protein phosphatase using photocaged, unnatural amino acids and use it to study...
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Nature Portfolio
2019
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oai:doaj.org-article:27c7f695325c479fbb77f72e954f51e92021-12-02T15:35:28ZOptical control of protein phosphatase function10.1038/s41467-019-12260-z2041-1723https://doaj.org/article/27c7f695325c479fbb77f72e954f51e92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12260-zhttps://doaj.org/toc/2041-1723Protein phosphatases play an essential role in signal transduction, but are understudied due to the difficulties in detecting phosphate removal and the lack of good inhibitors. Here the authors develop a light-activated protein phosphatase using photocaged, unnatural amino acids and use it to study ERK nuclear translocation.Taylor M. CourtneyAlexander DeitersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Taylor M. Courtney Alexander Deiters Optical control of protein phosphatase function |
| description |
Protein phosphatases play an essential role in signal transduction, but are understudied due to the difficulties in detecting phosphate removal and the lack of good inhibitors. Here the authors develop a light-activated protein phosphatase using photocaged, unnatural amino acids and use it to study ERK nuclear translocation. |
| format |
article |
| author |
Taylor M. Courtney Alexander Deiters |
| author_facet |
Taylor M. Courtney Alexander Deiters |
| author_sort |
Taylor M. Courtney |
| title |
Optical control of protein phosphatase function |
| title_short |
Optical control of protein phosphatase function |
| title_full |
Optical control of protein phosphatase function |
| title_fullStr |
Optical control of protein phosphatase function |
| title_full_unstemmed |
Optical control of protein phosphatase function |
| title_sort |
optical control of protein phosphatase function |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/27c7f695325c479fbb77f72e954f51e9 |
| work_keys_str_mv |
AT taylormcourtney opticalcontrolofproteinphosphatasefunction AT alexanderdeiters opticalcontrolofproteinphosphatasefunction |
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1718386522739179520 |