Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution

Pati Aji Achdiat, Kristina Makarti Adriyani, Argani Gracias Pospos, Rasmia Rowawi, Reti Hindritiani, Oki Suwarsa, Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Pati Aji AchdiatDep...

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Autores principales:	Achdiat PA, Adriyani KM, Pospos AG, Rowawi R, Hindritiani R, Suwarsa O, Gunawan H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	eyelids giant molluscum contagiosum hiv potassium hydroxide solution Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/27c8648b16164def8956156a98fa424d
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spelling	oai:doaj.org-article:27c8648b16164def8956156a98fa424d2021-11-21T19:08:51ZTwo Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution1179-1373https://doaj.org/article/27c8648b16164def8956156a98fa424d2021-11-01T00:00:00Zhttps://www.dovepress.com/two-cases-of-giant-molluscum-contagiosum-on-the-eyelids-of-hiv-patient-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Pati Aji Achdiat, Kristina Makarti Adriyani, Argani Gracias Pospos, Rasmia Rowawi, Reti Hindritiani, Oki Suwarsa, Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Pati Aji AchdiatDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, IndonesiaEmail pati.aji.achdiat@unpad.ac.idAbstract: Molluscum contagiosum (MC) is an infectious disease caused by the MC virus. In human immunodeficiency virus (HIV) patients, MC has an atypical predilection and prominence, sometimes measuring more than 1 cm in diameter, known as giant MC. Giant MC lesions on the eyelids are rare. There is no standardized therapy for eyelids MC in HIV patients. Antiretroviral (ARV) administration is recommended as the primary treatment for MC in HIV patients along with other treatment modalities, such as potassium hydroxide (KOH). The 20% KOH solution is a keratolytic agent with good efficacy as MC therapy. Two cases of giant MC on the eyelids of stage 2 HIV patients with respective CD4+ of 31 cells/μL and 46 cells/μL were reported. The lesions consisted of multiple confluent papules with central umbilication, and Tzanck smear revealed Henderson–Patterson bodies. Both patients were treated with ARV and self-applied 20% KOH solution once daily. The lesions improved after four weeks of therapy in both patients with most of the lesions diminished. The successful treatment with 20% KOH solution for giant MC on the eyelids of HIV patients observed in the current study provides evidence that treatment with this solution yielded prompt results, is non-toxic, and can be self-applied.Keywords: eyelids, giant molluscum contagiosum, HIV, potassium hydroxide solution, KOH, human immunodeficiency virusAchdiat PAAdriyani KMPospos AGRowawi RHindritiani RSuwarsa OGunawan HDove Medical Pressarticleeyelidsgiant molluscum contagiosumhivpotassium hydroxide solutionImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 993-997 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	eyelids giant molluscum contagiosum hiv potassium hydroxide solution Immunologic diseases. Allergy RC581-607
spellingShingle	eyelids giant molluscum contagiosum hiv potassium hydroxide solution Immunologic diseases. Allergy RC581-607 Achdiat PA Adriyani KM Pospos AG Rowawi R Hindritiani R Suwarsa O Gunawan H Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
description	Pati Aji Achdiat, Kristina Makarti Adriyani, Argani Gracias Pospos, Rasmia Rowawi, Reti Hindritiani, Oki Suwarsa, Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, IndonesiaCorrespondence: Pati Aji AchdiatDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, IndonesiaEmail pati.aji.achdiat@unpad.ac.idAbstract: Molluscum contagiosum (MC) is an infectious disease caused by the MC virus. In human immunodeficiency virus (HIV) patients, MC has an atypical predilection and prominence, sometimes measuring more than 1 cm in diameter, known as giant MC. Giant MC lesions on the eyelids are rare. There is no standardized therapy for eyelids MC in HIV patients. Antiretroviral (ARV) administration is recommended as the primary treatment for MC in HIV patients along with other treatment modalities, such as potassium hydroxide (KOH). The 20% KOH solution is a keratolytic agent with good efficacy as MC therapy. Two cases of giant MC on the eyelids of stage 2 HIV patients with respective CD4+ of 31 cells/μL and 46 cells/μL were reported. The lesions consisted of multiple confluent papules with central umbilication, and Tzanck smear revealed Henderson–Patterson bodies. Both patients were treated with ARV and self-applied 20% KOH solution once daily. The lesions improved after four weeks of therapy in both patients with most of the lesions diminished. The successful treatment with 20% KOH solution for giant MC on the eyelids of HIV patients observed in the current study provides evidence that treatment with this solution yielded prompt results, is non-toxic, and can be self-applied.Keywords: eyelids, giant molluscum contagiosum, HIV, potassium hydroxide solution, KOH, human immunodeficiency virus
format	article
author	Achdiat PA Adriyani KM Pospos AG Rowawi R Hindritiani R Suwarsa O Gunawan H
author_facet	Achdiat PA Adriyani KM Pospos AG Rowawi R Hindritiani R Suwarsa O Gunawan H
author_sort	Achdiat PA
title	Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
title_short	Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
title_full	Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
title_fullStr	Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
title_full_unstemmed	Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution
title_sort	two cases of giant molluscum contagiosum on the eyelids of hiv patients successfully treated with adjuvant self-applied topical 20% potassium hydroxide solution
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/27c8648b16164def8956156a98fa424d
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Two Cases of Giant Molluscum Contagiosum on the Eyelids of HIV Patients Successfully Treated with Adjuvant Self-Applied Topical 20% Potassium Hydroxide Solution

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