An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that does not inhibit PDE3A activity but induces apopto...

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Autores principales: Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma, Shuanhu Gao, Xiangbing Qi
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/27c89d5e7ff7496cb22ff33c146a9636
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spelling oai:doaj.org-article:27c89d5e7ff7496cb22ff33c146a96362021-12-02T16:05:51ZAn alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity10.1038/s41467-020-17052-42041-1723https://doaj.org/article/27c89d5e7ff7496cb22ff33c146a96362020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17052-4https://doaj.org/toc/2041-1723PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that does not inhibit PDE3A activity but induces apoptosis by enabling a complex formation between PDE3A and SLFN12.Youwei AiHaibing HePeihao ChenBo YanWenbin ZhangZhangcheng DingDianrong LiJie ChenYan MaYang CaoJie ZhuJiaojiao LiJinjie OuShan DuXiaodong WangJianzhang MaShuanhu GaoXiangbing QiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Youwei Ai
Haibing He
Peihao Chen
Bo Yan
Wenbin Zhang
Zhangcheng Ding
Dianrong Li
Jie Chen
Yan Ma
Yang Cao
Jie Zhu
Jiaojiao Li
Jinjie Ou
Shan Du
Xiaodong Wang
Jianzhang Ma
Shuanhu Gao
Xiangbing Qi
An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
description PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that does not inhibit PDE3A activity but induces apoptosis by enabling a complex formation between PDE3A and SLFN12.
format article
author Youwei Ai
Haibing He
Peihao Chen
Bo Yan
Wenbin Zhang
Zhangcheng Ding
Dianrong Li
Jie Chen
Yan Ma
Yang Cao
Jie Zhu
Jiaojiao Li
Jinjie Ou
Shan Du
Xiaodong Wang
Jianzhang Ma
Shuanhu Gao
Xiangbing Qi
author_facet Youwei Ai
Haibing He
Peihao Chen
Bo Yan
Wenbin Zhang
Zhangcheng Ding
Dianrong Li
Jie Chen
Yan Ma
Yang Cao
Jie Zhu
Jiaojiao Li
Jinjie Ou
Shan Du
Xiaodong Wang
Jianzhang Ma
Shuanhu Gao
Xiangbing Qi
author_sort Youwei Ai
title An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
title_short An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
title_full An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
title_fullStr An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
title_full_unstemmed An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
title_sort alkaloid initiates phosphodiesterase 3a–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/27c89d5e7ff7496cb22ff33c146a9636
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