TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

Mutations in the TRPV4 channel cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here the authors reveal that TRPV4 activation causes dose-dependent, CaMKII-mediated neuronal dysfunction and axonal degeneration via disruption of mitochondrial axonal transport.

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Autores principales: Brian M. Woolums, Brett A. McCray, Hyun Sung, Masashi Tabuchi, Jeremy M. Sullivan, Kendra Takle Ruppell, Yunpeng Yang, Catherine Mamah, William H. Aisenberg, Pamela C. Saavedra-Rivera, Bryan S. Larin, Alexander R. Lau, Douglas N. Robinson, Yang Xiang, Mark N. Wu, Charlotte J. Sumner, Thomas E. Lloyd
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/27caf567bfbb4b33b6d71b47ffe0ae8f
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spelling oai:doaj.org-article:27caf567bfbb4b33b6d71b47ffe0ae8f2021-12-02T14:47:29ZTRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+10.1038/s41467-020-16411-52041-1723https://doaj.org/article/27caf567bfbb4b33b6d71b47ffe0ae8f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16411-5https://doaj.org/toc/2041-1723Mutations in the TRPV4 channel cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here the authors reveal that TRPV4 activation causes dose-dependent, CaMKII-mediated neuronal dysfunction and axonal degeneration via disruption of mitochondrial axonal transport.Brian M. WoolumsBrett A. McCrayHyun SungMasashi TabuchiJeremy M. SullivanKendra Takle RuppellYunpeng YangCatherine MamahWilliam H. AisenbergPamela C. Saavedra-RiveraBryan S. LarinAlexander R. LauDouglas N. RobinsonYang XiangMark N. WuCharlotte J. SumnerThomas E. LloydNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Brian M. Woolums
Brett A. McCray
Hyun Sung
Masashi Tabuchi
Jeremy M. Sullivan
Kendra Takle Ruppell
Yunpeng Yang
Catherine Mamah
William H. Aisenberg
Pamela C. Saavedra-Rivera
Bryan S. Larin
Alexander R. Lau
Douglas N. Robinson
Yang Xiang
Mark N. Wu
Charlotte J. Sumner
Thomas E. Lloyd
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
description Mutations in the TRPV4 channel cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here the authors reveal that TRPV4 activation causes dose-dependent, CaMKII-mediated neuronal dysfunction and axonal degeneration via disruption of mitochondrial axonal transport.
format article
author Brian M. Woolums
Brett A. McCray
Hyun Sung
Masashi Tabuchi
Jeremy M. Sullivan
Kendra Takle Ruppell
Yunpeng Yang
Catherine Mamah
William H. Aisenberg
Pamela C. Saavedra-Rivera
Bryan S. Larin
Alexander R. Lau
Douglas N. Robinson
Yang Xiang
Mark N. Wu
Charlotte J. Sumner
Thomas E. Lloyd
author_facet Brian M. Woolums
Brett A. McCray
Hyun Sung
Masashi Tabuchi
Jeremy M. Sullivan
Kendra Takle Ruppell
Yunpeng Yang
Catherine Mamah
William H. Aisenberg
Pamela C. Saavedra-Rivera
Bryan S. Larin
Alexander R. Lau
Douglas N. Robinson
Yang Xiang
Mark N. Wu
Charlotte J. Sumner
Thomas E. Lloyd
author_sort Brian M. Woolums
title TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
title_short TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
title_full TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
title_fullStr TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
title_full_unstemmed TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
title_sort trpv4 disrupts mitochondrial transport and causes axonal degeneration via a camkii-dependent elevation of intracellular ca2+
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/27caf567bfbb4b33b6d71b47ffe0ae8f
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