Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection
In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor (⍺1-AR) ant...
Guardado en:
Autores principales: | Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
eLife Sciences Publications Ltd
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/27cc1efbc7b74373ace05076206c199b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
COVID-19 Hyperinflammation: What about Neutrophils?
por: Athanasios Didangelos
Publicado: (2020) -
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
por: Michael S. Hwang, et al.
Publicado: (2021) -
A nanotrap improves survival in severe sepsis by attenuating hyperinflammation
por: Changying Shi, et al.
Publicado: (2020) -
The treatment with Jusvinza reduces hyperinflammation and hypercoagulation in critical ill patients with COVID-19
por: Rafael Venegas Rodríguez, et al.
Publicado: (2021) -
Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE
por: Travis B. Nielsen, et al.
Publicado: (2017)