A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional his...

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Autores principales: Yixiang Liu, Joshua Rose, Shaojia Huang, Yangbo Hu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu, Pei Zhou, Ling Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/27cc50a1f81a40c1b8104aee29888793
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spelling oai:doaj.org-article:27cc50a1f81a40c1b8104aee298887932021-12-02T15:38:55ZA pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases10.1038/s41467-017-02310-92041-1723https://doaj.org/article/27cc50a1f81a40c1b8104aee298887932017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02310-9https://doaj.org/toc/2041-1723Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional histidine kinases.Yixiang LiuJoshua RoseShaojia HuangYangbo HuQiong WuDan WangConggang LiMaili LiuPei ZhouLing JiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yixiang Liu
Joshua Rose
Shaojia Huang
Yangbo Hu
Qiong Wu
Dan Wang
Conggang Li
Maili Liu
Pei Zhou
Ling Jiang
A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
description Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional histidine kinases.
format article
author Yixiang Liu
Joshua Rose
Shaojia Huang
Yangbo Hu
Qiong Wu
Dan Wang
Conggang Li
Maili Liu
Pei Zhou
Ling Jiang
author_facet Yixiang Liu
Joshua Rose
Shaojia Huang
Yangbo Hu
Qiong Wu
Dan Wang
Conggang Li
Maili Liu
Pei Zhou
Ling Jiang
author_sort Yixiang Liu
title A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
title_short A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
title_full A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
title_fullStr A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
title_full_unstemmed A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
title_sort ph-gated conformational switch regulates the phosphatase activity of bifunctional hiska-family histidine kinases
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/27cc50a1f81a40c1b8104aee29888793
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