Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Abstract Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regula...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Timon Damelang, Elizabeth H. Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W. Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J. Kent, Stephen J. Rogerson, Amy W. Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27cc8554f9a544d6a5a259ece4468ade
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:27cc8554f9a544d6a5a259ece4468ade
record_format	dspace
spelling	oai:doaj.org-article:27cc8554f9a544d6a5a259ece4468ade2021-12-02T12:11:34ZAntibody mediated activation of natural killer cells in malaria exposed pregnant women10.1038/s41598-021-83093-42045-2322https://doaj.org/article/27cc8554f9a544d6a5a259ece4468ade2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83093-4https://doaj.org/toc/2045-2322Abstract Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.Timon DamelangElizabeth H. AitkenWina HasangEster LopezMartin KillianHolger W. UngerAli SalantiAlexis ShubElizabeth McCarthyKatherine KedzierskaMartha LappasStephen J. KentStephen J. RogersonAmy W. ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timon Damelang Elizabeth H. Aitken Wina Hasang Ester Lopez Martin Killian Holger W. Unger Ali Salanti Alexis Shub Elizabeth McCarthy Katherine Kedzierska Martha Lappas Stephen J. Kent Stephen J. Rogerson Amy W. Chung Antibody mediated activation of natural killer cells in malaria exposed pregnant women
description	Abstract Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.
format	article
author	Timon Damelang Elizabeth H. Aitken Wina Hasang Ester Lopez Martin Killian Holger W. Unger Ali Salanti Alexis Shub Elizabeth McCarthy Katherine Kedzierska Martha Lappas Stephen J. Kent Stephen J. Rogerson Amy W. Chung
author_facet	Timon Damelang Elizabeth H. Aitken Wina Hasang Ester Lopez Martin Killian Holger W. Unger Ali Salanti Alexis Shub Elizabeth McCarthy Katherine Kedzierska Martha Lappas Stephen J. Kent Stephen J. Rogerson Amy W. Chung
author_sort	Timon Damelang
title	Antibody mediated activation of natural killer cells in malaria exposed pregnant women
title_short	Antibody mediated activation of natural killer cells in malaria exposed pregnant women
title_full	Antibody mediated activation of natural killer cells in malaria exposed pregnant women
title_fullStr	Antibody mediated activation of natural killer cells in malaria exposed pregnant women
title_full_unstemmed	Antibody mediated activation of natural killer cells in malaria exposed pregnant women
title_sort	antibody mediated activation of natural killer cells in malaria exposed pregnant women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27cc8554f9a544d6a5a259ece4468ade
work_keys_str_mv	AT timondamelang antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT elizabethhaitken antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT winahasang antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT esterlopez antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT martinkillian antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT holgerwunger antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT alisalanti antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT alexisshub antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT elizabethmccarthy antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT katherinekedzierska antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT marthalappas antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT stephenjkent antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT stephenjrogerson antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen AT amywchung antibodymediatedactivationofnaturalkillercellsinmalariaexposedpregnantwomen
_version_	1718394617375752192

Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Ejemplares similares