A bottom-up model of functional outcome in schizophrenia

Abstract Schizophrenia results in poor functional outcomes owing to numerous factors. This study provides the first test of a bottom-up causal model of functional outcome in schizophrenia, using neurocognition, vocal emotional cognition, alexithymia, and negative symptoms as predictors of functional...

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Autores principales:	Hongge Luo, Yanli Zhao, Fengmei Fan, Hongzhen Fan, Yunhui Wang, Wei Qu, Zhiren Wang, Yunlong Tan, Xiujun Zhang, Shuping Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27d4127421954004be6c4d2ec27c39a1
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spelling	oai:doaj.org-article:27d4127421954004be6c4d2ec27c39a12021-12-02T14:21:11ZA bottom-up model of functional outcome in schizophrenia10.1038/s41598-021-87172-42045-2322https://doaj.org/article/27d4127421954004be6c4d2ec27c39a12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87172-4https://doaj.org/toc/2045-2322Abstract Schizophrenia results in poor functional outcomes owing to numerous factors. This study provides the first test of a bottom-up causal model of functional outcome in schizophrenia, using neurocognition, vocal emotional cognition, alexithymia, and negative symptoms as predictors of functional outcome. We investigated a cross-sectional sample of 135 individuals with schizophrenia and 78 controls. Using a series of structural equation modelling analyses, a single pathway was generated among scores from the MATRICS Consensus Cognitive Battery (MCCB), vocal emotion recognition test, Toronto Alexithymia Scale (TAS), Brief Negative Symptom Scale, and the Personal and Social Performance Scale. The scores for each dimension of the MCCB in the schizophrenia group were significantly lower than that in the control group. The recognition accuracy for different emotions (anger, disgust, fear, sadness, surprise, and satire, but not calm was significantly lower in the schizophrenia group than in the control group. Moreover, the scores on the three dimensions of TAS were significantly higher in the schizophrenia group than in the control group. On path analysis modelling, the proposed bottom-up causal model showed a strong fit with the data and formed a single pathway, from neurocognition to vocal emotional cognition, to alexithymia, to negative symptoms, and to poor functional outcomes. The study results strongly support the proposed bottom-up causal model of functional outcome in schizophrenia. The model could be used to better understand the causal factors related to the functional outcome, as well as for the development of intervention strategies to improve functional outcomes in schizophrenia.Hongge LuoYanli ZhaoFengmei FanHongzhen FanYunhui WangWei QuZhiren WangYunlong TanXiujun ZhangShuping TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongge Luo Yanli Zhao Fengmei Fan Hongzhen Fan Yunhui Wang Wei Qu Zhiren Wang Yunlong Tan Xiujun Zhang Shuping Tan A bottom-up model of functional outcome in schizophrenia
description	Abstract Schizophrenia results in poor functional outcomes owing to numerous factors. This study provides the first test of a bottom-up causal model of functional outcome in schizophrenia, using neurocognition, vocal emotional cognition, alexithymia, and negative symptoms as predictors of functional outcome. We investigated a cross-sectional sample of 135 individuals with schizophrenia and 78 controls. Using a series of structural equation modelling analyses, a single pathway was generated among scores from the MATRICS Consensus Cognitive Battery (MCCB), vocal emotion recognition test, Toronto Alexithymia Scale (TAS), Brief Negative Symptom Scale, and the Personal and Social Performance Scale. The scores for each dimension of the MCCB in the schizophrenia group were significantly lower than that in the control group. The recognition accuracy for different emotions (anger, disgust, fear, sadness, surprise, and satire, but not calm was significantly lower in the schizophrenia group than in the control group. Moreover, the scores on the three dimensions of TAS were significantly higher in the schizophrenia group than in the control group. On path analysis modelling, the proposed bottom-up causal model showed a strong fit with the data and formed a single pathway, from neurocognition to vocal emotional cognition, to alexithymia, to negative symptoms, and to poor functional outcomes. The study results strongly support the proposed bottom-up causal model of functional outcome in schizophrenia. The model could be used to better understand the causal factors related to the functional outcome, as well as for the development of intervention strategies to improve functional outcomes in schizophrenia.
format	article
author	Hongge Luo Yanli Zhao Fengmei Fan Hongzhen Fan Yunhui Wang Wei Qu Zhiren Wang Yunlong Tan Xiujun Zhang Shuping Tan
author_facet	Hongge Luo Yanli Zhao Fengmei Fan Hongzhen Fan Yunhui Wang Wei Qu Zhiren Wang Yunlong Tan Xiujun Zhang Shuping Tan
author_sort	Hongge Luo
title	A bottom-up model of functional outcome in schizophrenia
title_short	A bottom-up model of functional outcome in schizophrenia
title_full	A bottom-up model of functional outcome in schizophrenia
title_fullStr	A bottom-up model of functional outcome in schizophrenia
title_full_unstemmed	A bottom-up model of functional outcome in schizophrenia
title_sort	bottom-up model of functional outcome in schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27d4127421954004be6c4d2ec27c39a1
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A bottom-up model of functional outcome in schizophrenia

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