Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children

Walid Saeed, Molham AL-Habori, Riyadh Saif-Ali, Ekram Al-Eryani Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, YemenCorrespondence: Molham AL-Habori Email malhabori@hotmail.comPurpose: In view of the high rate of obesity and p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saeed W, AL-Habori M, Saif-Ali R, Al-Eryani E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	metabolic syndrome prediabetes obesity insulin resistance school-aged children. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/27d4fdd40e894a31b5e66bc7f57a1e5d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:27d4fdd40e894a31b5e66bc7f57a1e5d
record_format	dspace
spelling	oai:doaj.org-article:27d4fdd40e894a31b5e66bc7f57a1e5d2021-12-02T08:31:52ZMetabolic Syndrome and Prediabetes Among Yemeni School-Aged Children1178-7007https://doaj.org/article/27d4fdd40e894a31b5e66bc7f57a1e5d2020-07-01T00:00:00Zhttps://www.dovepress.com/metabolic-syndrome-and-prediabetes-among-yemeni-school-aged-children-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Walid Saeed, Molham AL-Habori, Riyadh Saif-Ali, Ekram Al-Eryani Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, YemenCorrespondence: Molham AL-Habori Email malhabori@hotmail.comPurpose: In view of the high rate of obesity and physical inactivity as well as the rising incidence of Type 2 DM among children in the neighboring Gulf countries and Middle East region; the aim of this study was, therefore, to determine the prevalence of metabolic syndrome (MetS) and prediabetes in Yemeni school-aged children.Patients and Methods: In this study, 1402 school children aged 12– 13 years old (grade 7) were recruited from public schools in the capital Sana’a during the period April–May 2013. Anthropometric measurements and BP were recorded and BMI was calculated. Fasting venous blood (5 mL) was collected for biochemical analysis including FBG, HbA1c, insulin and lipids profile. Insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were calculated.Results: The prevalence of prediabetes (as defined by impaired fasting glucose) and MetS (as classified by the IDF 2007) were 0.86% and 0.5%, respectively. Our results also showed 5.21% and 20.26% of the children to have two or one factor(s) of the MetS criteria fulfilled, respectively, with low HDL-c (17%) being the most prevalent MetS component, followed by metabolic glucose (8%), raised TG (5.3%), DBP (1.4%), and high WC (0.5%). Moreover, the prevalence of overweight and obesity was 4.2% and 2.8%, respectively; and about 1.2% of children had abnormal high insulin levels. Children with impaired fasting glucose (IFG) had increased HOMA-IR (p = 0.016) and SBP (p = 0.042) and decreased HDL-c (p = 0.034) and HOMA-β (p < 0.001); whereas obese children had increased WC (p < 0.001) and TG (p = 0.049).Conclusion: The main finding of this study is that Yemeni children are at potential risk of obesity, metabolic syndrome and prediabetes despite their low prevalences. These results highlight the need for early identification and close monitoring of children at risk of later Type 2 DM as an important primary care strategy that can effectively prevent or delay the onset of such condition.Keywords: metabolic syndrome, prediabetes, obesity, insulin resistance, school-aged childrenSaeed WAL-Habori MSaif-Ali RAl-Eryani EDove Medical Pressarticlemetabolic syndromeprediabetesobesityinsulin resistanceschool-aged children.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2563-2572 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic syndrome prediabetes obesity insulin resistance school-aged children. Specialties of internal medicine RC581-951
spellingShingle	metabolic syndrome prediabetes obesity insulin resistance school-aged children. Specialties of internal medicine RC581-951 Saeed W AL-Habori M Saif-Ali R Al-Eryani E Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
description	Walid Saeed, Molham AL-Habori, Riyadh Saif-Ali, Ekram Al-Eryani Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, YemenCorrespondence: Molham AL-Habori Email malhabori@hotmail.comPurpose: In view of the high rate of obesity and physical inactivity as well as the rising incidence of Type 2 DM among children in the neighboring Gulf countries and Middle East region; the aim of this study was, therefore, to determine the prevalence of metabolic syndrome (MetS) and prediabetes in Yemeni school-aged children.Patients and Methods: In this study, 1402 school children aged 12– 13 years old (grade 7) were recruited from public schools in the capital Sana’a during the period April–May 2013. Anthropometric measurements and BP were recorded and BMI was calculated. Fasting venous blood (5 mL) was collected for biochemical analysis including FBG, HbA1c, insulin and lipids profile. Insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were calculated.Results: The prevalence of prediabetes (as defined by impaired fasting glucose) and MetS (as classified by the IDF 2007) were 0.86% and 0.5%, respectively. Our results also showed 5.21% and 20.26% of the children to have two or one factor(s) of the MetS criteria fulfilled, respectively, with low HDL-c (17%) being the most prevalent MetS component, followed by metabolic glucose (8%), raised TG (5.3%), DBP (1.4%), and high WC (0.5%). Moreover, the prevalence of overweight and obesity was 4.2% and 2.8%, respectively; and about 1.2% of children had abnormal high insulin levels. Children with impaired fasting glucose (IFG) had increased HOMA-IR (p = 0.016) and SBP (p = 0.042) and decreased HDL-c (p = 0.034) and HOMA-β (p < 0.001); whereas obese children had increased WC (p < 0.001) and TG (p = 0.049).Conclusion: The main finding of this study is that Yemeni children are at potential risk of obesity, metabolic syndrome and prediabetes despite their low prevalences. These results highlight the need for early identification and close monitoring of children at risk of later Type 2 DM as an important primary care strategy that can effectively prevent or delay the onset of such condition.Keywords: metabolic syndrome, prediabetes, obesity, insulin resistance, school-aged children
format	article
author	Saeed W AL-Habori M Saif-Ali R Al-Eryani E
author_facet	Saeed W AL-Habori M Saif-Ali R Al-Eryani E
author_sort	Saeed W
title	Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_short	Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_full	Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_fullStr	Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_full_unstemmed	Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_sort	metabolic syndrome and prediabetes among yemeni school-aged children
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/27d4fdd40e894a31b5e66bc7f57a1e5d
work_keys_str_mv	AT saeedw metabolicsyndromeandprediabetesamongyemenischoolagedchildren AT alhaborim metabolicsyndromeandprediabetesamongyemenischoolagedchildren AT saifalir metabolicsyndromeandprediabetesamongyemenischoolagedchildren AT aleryanie metabolicsyndromeandprediabetesamongyemenischoolagedchildren
_version_	1718398471914913792

Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children

Ejemplares similares