Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.

<h4>Purpose</h4>The purpose of this hospital-based case-control study was to evaluate the patient-related risk factors for aseptic loosening after total hip arthroplasty (THA) and total knee arthroplasty (TKA) in Chinese patients.<h4>Methods</h4>From January 2000 to December...

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Autores principales:	Chuanlong Wu, Xinhua Qu, Yuanqing Mao, Huiwu Li, Fengxiang Liu, Zhenan Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27d68969693c4057a9824c4ac55d729d
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spelling	oai:doaj.org-article:27d68969693c4057a9824c4ac55d729d2021-11-18T08:37:39ZDevelopmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.1932-620310.1371/journal.pone.0085562https://doaj.org/article/27d68969693c4057a9824c4ac55d729d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454888/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>The purpose of this hospital-based case-control study was to evaluate the patient-related risk factors for aseptic loosening after total hip arthroplasty (THA) and total knee arthroplasty (TKA) in Chinese patients.<h4>Methods</h4>From January 2000 to December 2012, 67 patients undergoing THA and TKA who developed aseptic loosening were detected as case subjects and 336 patients without aseptic loosening, matched by the year of index surgery and type of surgery, were selected as controls. Conditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs).<h4>Results</h4>The demographic factors and comorbid conditions associated with a risk-adjusted increase in aseptic loosening (in decreasing order of significance) were a rural place of residence (OR = 2.28; 95% CI: 1.21-4.30; p = 0.011), body mass index (BMI) ≥ 28 kg/m(2) (vs. 18.5-28 kg/m(2)) (OR = 2.29; 95% CI: 1.19-4.41; p = 0.013), developmental dysplasia of the hip (DDH) (OR = 2.91; 95% CI: 1.11-7.66; p = 0.030), tobacco abuse (OR = 2.88; 95% CI: 1.05-7.89; p = 0.039), and age <45 years (vs. 45-65 years) (OR = 2.63; 95% CI: 1.01-6.80; p = 0.047).<h4>Conclusions</h4>Patients aged <45 years and those with a BMI of ≥ 28 kg/m(2), a preoperative diagnosis of DDH, history of tobacco abuse, or living in rural areas are at increased risk for aseptic loosening after THA and TKA in Chinese population. Additional systematic large-scale studies are needed to verify these results.Chuanlong WuXinhua QuYuanqing MaoHuiwu LiFengxiang LiuZhenan ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85562 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chuanlong Wu Xinhua Qu Yuanqing Mao Huiwu Li Fengxiang Liu Zhenan Zhu Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.
description	<h4>Purpose</h4>The purpose of this hospital-based case-control study was to evaluate the patient-related risk factors for aseptic loosening after total hip arthroplasty (THA) and total knee arthroplasty (TKA) in Chinese patients.<h4>Methods</h4>From January 2000 to December 2012, 67 patients undergoing THA and TKA who developed aseptic loosening were detected as case subjects and 336 patients without aseptic loosening, matched by the year of index surgery and type of surgery, were selected as controls. Conditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs).<h4>Results</h4>The demographic factors and comorbid conditions associated with a risk-adjusted increase in aseptic loosening (in decreasing order of significance) were a rural place of residence (OR = 2.28; 95% CI: 1.21-4.30; p = 0.011), body mass index (BMI) ≥ 28 kg/m(2) (vs. 18.5-28 kg/m(2)) (OR = 2.29; 95% CI: 1.19-4.41; p = 0.013), developmental dysplasia of the hip (DDH) (OR = 2.91; 95% CI: 1.11-7.66; p = 0.030), tobacco abuse (OR = 2.88; 95% CI: 1.05-7.89; p = 0.039), and age <45 years (vs. 45-65 years) (OR = 2.63; 95% CI: 1.01-6.80; p = 0.047).<h4>Conclusions</h4>Patients aged <45 years and those with a BMI of ≥ 28 kg/m(2), a preoperative diagnosis of DDH, history of tobacco abuse, or living in rural areas are at increased risk for aseptic loosening after THA and TKA in Chinese population. Additional systematic large-scale studies are needed to verify these results.
format	article
author	Chuanlong Wu Xinhua Qu Yuanqing Mao Huiwu Li Fengxiang Liu Zhenan Zhu
author_facet	Chuanlong Wu Xinhua Qu Yuanqing Mao Huiwu Li Fengxiang Liu Zhenan Zhu
author_sort	Chuanlong Wu
title	Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.
title_short	Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.
title_full	Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.
title_fullStr	Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.
title_full_unstemmed	Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.
title_sort	developmental dysplasia of the hip, age, bmi, place of residence and tobacco abuse increase the odds of aseptic loosening in chinese patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/27d68969693c4057a9824c4ac55d729d
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Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients.

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