The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women

Mingyan Yao,1,2,* Hongzhou Liu,1,* Bing Li,1 Yang Liu,1 Yiming Mu1 1Department of Endocrinology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding, 071000, People&am...

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Autores principales:	Yao M, Liu H, Li B, Liu Y, Mu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	age urinary albumin-creatinine ratio menopause Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/27dcdc35fa8049079060a5369958b69b
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spelling	oai:doaj.org-article:27dcdc35fa8049079060a5369958b69b2021-12-02T16:22:18ZThe Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women1178-7007https://doaj.org/article/27dcdc35fa8049079060a5369958b69b2021-02-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-earlier-onset-of-natural-menopause-and-elevat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Mingyan Yao,1,2,* Hongzhou Liu,1,* Bing Li,1 Yang Liu,1 Yiming Mu1 1Department of Endocrinology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiming MuDepartment of Endocrinology, Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Beijing, 100853, People’s Republic of ChinaEmail muyiming@301hospital.com.cnPurpose: There is a close correlation between menopausal age and cardiovascular disease (CVD) risk. Some research suggests that this risk is attributable to an elevated urinary albumin-creatinine ratio (UACR), but further work is needed to explore the link between UACR and age at time of menopause.Patients and Methods: Data analyzed in the present study were derived from seven regional centers participating in the REACTION study. A total of 21,672 postmenopausal women met with our study inclusion and exclusion criteria, and were split into three groups based upon their age at onset of natural menopause. A UACR ≥ 30 mg/g was the primary outcome measure for this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a logistic regression approach.Results: Relative to women who were 46– 50 years old at time of natural menopause, those with an earlier onset of menopause (≤ 45 years) exhibited an increased risk of UACR elevation following adjustment for confounding variables (OR: 1.18, 95% CI: 1.04– 1.33), whereas the opposite was true for women with a later age of menopause onset (> 50 years) (OR: 0.86, 95% CI: 0.78– 0.94). For every 1-year delay in the onset of menopause, UACR risk fell by 3% (OR: 0.97, 95% CI: 0.96– 0.98).Conclusion: In summary, early menopause (≤ 45 years old) was linked to a higher risk of UACR elevation in postmenopausal women. However, further work will be needed to understand the mechanistic basis for these findings.Keywords: age, urinary albumin-creatinine ratio, menopauseYao MLiu HLi BLiu YMu YDove Medical Pressarticleageurinary albumin-creatinine ratiomenopauseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 847-856 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	age urinary albumin-creatinine ratio menopause Specialties of internal medicine RC581-951
spellingShingle	age urinary albumin-creatinine ratio menopause Specialties of internal medicine RC581-951 Yao M Liu H Li B Liu Y Mu Y The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women
description	Mingyan Yao,1,2,* Hongzhou Liu,1,* Bing Li,1 Yang Liu,1 Yiming Mu1 1Department of Endocrinology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiming MuDepartment of Endocrinology, Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Beijing, 100853, People’s Republic of ChinaEmail muyiming@301hospital.com.cnPurpose: There is a close correlation between menopausal age and cardiovascular disease (CVD) risk. Some research suggests that this risk is attributable to an elevated urinary albumin-creatinine ratio (UACR), but further work is needed to explore the link between UACR and age at time of menopause.Patients and Methods: Data analyzed in the present study were derived from seven regional centers participating in the REACTION study. A total of 21,672 postmenopausal women met with our study inclusion and exclusion criteria, and were split into three groups based upon their age at onset of natural menopause. A UACR ≥ 30 mg/g was the primary outcome measure for this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a logistic regression approach.Results: Relative to women who were 46– 50 years old at time of natural menopause, those with an earlier onset of menopause (≤ 45 years) exhibited an increased risk of UACR elevation following adjustment for confounding variables (OR: 1.18, 95% CI: 1.04– 1.33), whereas the opposite was true for women with a later age of menopause onset (> 50 years) (OR: 0.86, 95% CI: 0.78– 0.94). For every 1-year delay in the onset of menopause, UACR risk fell by 3% (OR: 0.97, 95% CI: 0.96– 0.98).Conclusion: In summary, early menopause (≤ 45 years old) was linked to a higher risk of UACR elevation in postmenopausal women. However, further work will be needed to understand the mechanistic basis for these findings.Keywords: age, urinary albumin-creatinine ratio, menopause
format	article
author	Yao M Liu H Li B Liu Y Mu Y
author_facet	Yao M Liu H Li B Liu Y Mu Y
author_sort	Yao M
title	The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women
title_short	The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women
title_full	The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women
title_fullStr	The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women
title_full_unstemmed	The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women
title_sort	relationship between earlier onset of natural menopause and elevated urinary albumin-creatinine ratio in postmenopausal chinese women
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/27dcdc35fa8049079060a5369958b69b
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The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women

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