CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells

CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells

Regulatory B cells (Breg) are known to suppress immune responses by secreting interleukin-10 (IL-10). Here the authors show that, alternatively, Bregs may also present lipid antigens on surface CD1d to induce IFN-γ production from invariant natural killer cells to ameliorate experimental arthritis v...

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Autores principales: K. Oleinika, E. C. Rosser, D. E. Matei, K. Nistala, A. Bosma, I. Drozdov, C. Mauri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/27de2319a9434618ab16ff5bb9955596
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spelling oai:doaj.org-article:27de2319a9434618ab16ff5bb99555962021-12-02T15:34:26ZCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells10.1038/s41467-018-02911-y2041-1723https://doaj.org/article/27de2319a9434618ab16ff5bb99555962018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02911-yhttps://doaj.org/toc/2041-1723Regulatory B cells (Breg) are known to suppress immune responses by secreting interleukin-10 (IL-10). Here the authors show that, alternatively, Bregs may also present lipid antigens on surface CD1d to induce IFN-γ production from invariant natural killer cells to ameliorate experimental arthritis via IL-10-independent pathways.K. OleinikaE. C. RosserD. E. MateiK. NistalaA. BosmaI. DrozdovC. MauriNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
K. Oleinika
E. C. Rosser
D. E. Matei
K. Nistala
A. Bosma
I. Drozdov
C. Mauri
CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
description Regulatory B cells (Breg) are known to suppress immune responses by secreting interleukin-10 (IL-10). Here the authors show that, alternatively, Bregs may also present lipid antigens on surface CD1d to induce IFN-γ production from invariant natural killer cells to ameliorate experimental arthritis via IL-10-independent pathways.
format article
author K. Oleinika
E. C. Rosser
D. E. Matei
K. Nistala
A. Bosma
I. Drozdov
C. Mauri
author_facet K. Oleinika
E. C. Rosser
D. E. Matei
K. Nistala
A. Bosma
I. Drozdov
C. Mauri
author_sort K. Oleinika
title CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
title_short CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
title_full CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
title_fullStr CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
title_full_unstemmed CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
title_sort cd1d-dependent immune suppression mediated by regulatory b cells through modulations of inkt cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/27de2319a9434618ab16ff5bb9955596
work_keys_str_mv AT koleinika cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
AT ecrosser cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
AT dematei cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
AT knistala cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
AT abosma cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
AT idrozdov cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
AT cmauri cd1ddependentimmunesuppressionmediatedbyregulatorybcellsthroughmodulationsofinktcells
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