Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis

Background: The ALS diagnostic challenges necessitate more robust diagnostic and prognostic methods. A potential biomarker in this regard is the alterations of ferritin levels in the serum and CSF of patients compared to controls. Methods: The CSF and serum ferritin levels were measured in 50 ALS ca...

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Autores principales:	Parastou Paydarnia, Mahsa Mayeli, Mahan Shafie, Elmira Agah, Seyede Anis Hasani, Maryam Rashidi Jazani, Payam Sarraf
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	ALS Ferritin Serum CSF Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/27deca90576a4f7e8d2044e308426222
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spelling	oai:doaj.org-article:27deca90576a4f7e8d2044e3084262222021-11-26T04:35:28ZAlterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis2405-650210.1016/j.ensci.2021.100379https://doaj.org/article/27deca90576a4f7e8d2044e3084262222021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405650221000721https://doaj.org/toc/2405-6502Background: The ALS diagnostic challenges necessitate more robust diagnostic and prognostic methods. A potential biomarker in this regard is the alterations of ferritin levels in the serum and CSF of patients compared to controls. Methods: The CSF and serum ferritin levels were measured in 50 ALS cases and 50 control patients with predefined exclusion criteria. The ELISA method was utilized for laboratory measurement and was statistically analyzed using the SPSS. Results: Heightened serum ferritin levels in cases were not statistically significant. However, CSF ferritin levels were significantly higher in ALS patients (P < 0.001). Serum ferritin levels were significantly negatively correlated with the disease duration (P = 0.015) and were significantly positively correlated with the disease progression rate (DPR) (P = 0.012). Conclusion: Heightened CSF ferritin levels can be used for the diagnosis of ALS. The correlation between the serum ferritin levels with the DPR and its correlation with the disease duration suggests potential prognostic utilities.Parastou PaydarniaMahsa MayeliMahan ShafieElmira AgahSeyede Anis HasaniMaryam Rashidi JazaniPayam SarrafElsevierarticleALSFerritinSerumCSFNeurology. Diseases of the nervous systemRC346-429ENeNeurologicalSci, Vol 25, Iss , Pp 100379- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALS Ferritin Serum CSF Neurology. Diseases of the nervous system RC346-429
spellingShingle	ALS Ferritin Serum CSF Neurology. Diseases of the nervous system RC346-429 Parastou Paydarnia Mahsa Mayeli Mahan Shafie Elmira Agah Seyede Anis Hasani Maryam Rashidi Jazani Payam Sarraf Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
description	Background: The ALS diagnostic challenges necessitate more robust diagnostic and prognostic methods. A potential biomarker in this regard is the alterations of ferritin levels in the serum and CSF of patients compared to controls. Methods: The CSF and serum ferritin levels were measured in 50 ALS cases and 50 control patients with predefined exclusion criteria. The ELISA method was utilized for laboratory measurement and was statistically analyzed using the SPSS. Results: Heightened serum ferritin levels in cases were not statistically significant. However, CSF ferritin levels were significantly higher in ALS patients (P < 0.001). Serum ferritin levels were significantly negatively correlated with the disease duration (P = 0.015) and were significantly positively correlated with the disease progression rate (DPR) (P = 0.012). Conclusion: Heightened CSF ferritin levels can be used for the diagnosis of ALS. The correlation between the serum ferritin levels with the DPR and its correlation with the disease duration suggests potential prognostic utilities.
format	article
author	Parastou Paydarnia Mahsa Mayeli Mahan Shafie Elmira Agah Seyede Anis Hasani Maryam Rashidi Jazani Payam Sarraf
author_facet	Parastou Paydarnia Mahsa Mayeli Mahan Shafie Elmira Agah Seyede Anis Hasani Maryam Rashidi Jazani Payam Sarraf
author_sort	Parastou Paydarnia
title	Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
title_short	Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
title_full	Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
title_fullStr	Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
title_full_unstemmed	Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
title_sort	alterations of the serum and csf ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/27deca90576a4f7e8d2044e308426222
work_keys_str_mv	AT parastoupaydarnia alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis AT mahsamayeli alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis AT mahanshafie alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis AT elmiraagah alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis AT seyedeanishasani alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis AT maryamrashidijazani alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis AT payamsarraf alterationsoftheserumandcsfferritinlevelsandthediagnosisandprognosisofamyotrophiclateralsclerosis
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Alterations of the serum and CSF ferritin levels and the diagnosis and prognosis of amyotrophic lateral sclerosis

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