Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women

Abstract Understanding factors contributing to variation in ‘biological age’ is essential to understanding variation in susceptibility to disease and functional decline. One factor that could accelerate biological aging in women is reproduction. Pregnancy is characterized by extensive, energetically...

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Autores principales:	Talia N. Shirazi, Waylon J. Hastings, Asher Y. Rosinger, Calen P. Ryan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27e4ba3472bb491a91e560cf05395dc0
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spelling	oai:doaj.org-article:27e4ba3472bb491a91e560cf05395dc02021-12-02T16:09:10ZParity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women10.1038/s41598-020-77082-22045-2322https://doaj.org/article/27e4ba3472bb491a91e560cf05395dc02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77082-2https://doaj.org/toc/2045-2322Abstract Understanding factors contributing to variation in ‘biological age’ is essential to understanding variation in susceptibility to disease and functional decline. One factor that could accelerate biological aging in women is reproduction. Pregnancy is characterized by extensive, energetically-costly changes across numerous physiological systems. These ‘costs of reproduction’ may accumulate with each pregnancy, accelerating biological aging. Despite evidence for costs of reproduction using molecular and demographic measures, it is unknown whether parity is linked to commonly-used clinical measures of biological aging. We use data collected between 1999 and 2010 from the National Health and Nutrition Examination Survey (n = 4418) to test whether parity (number of live births) predicted four previously-validated composite measures of biological age and system integrity: Levine Method, homeostatic dysregulation, Klemera–Doubal method biological age, and allostatic load. Parity exhibited a U-shaped relationship with accelerated biological aging when controlling for chronological age, lifestyle, health-related, and demographic factors in post-menopausal, but not pre-menopausal, women, with biological age acceleration being lowest among post-menopausal women reporting between three and four live births. Our findings suggest a link between reproductive function and physiological dysregulation, and allude to possible compensatory mechanisms that buffer the effects of reproductive function on physiological dysregulation during a woman’s reproductive lifespan. Future work should continue to investigate links between parity, menopausal status, and biological age using targeted physiological measures and longitudinal studies.Talia N. ShiraziWaylon J. HastingsAsher Y. RosingerCalen P. RyanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Talia N. Shirazi Waylon J. Hastings Asher Y. Rosinger Calen P. Ryan Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
description	Abstract Understanding factors contributing to variation in ‘biological age’ is essential to understanding variation in susceptibility to disease and functional decline. One factor that could accelerate biological aging in women is reproduction. Pregnancy is characterized by extensive, energetically-costly changes across numerous physiological systems. These ‘costs of reproduction’ may accumulate with each pregnancy, accelerating biological aging. Despite evidence for costs of reproduction using molecular and demographic measures, it is unknown whether parity is linked to commonly-used clinical measures of biological aging. We use data collected between 1999 and 2010 from the National Health and Nutrition Examination Survey (n = 4418) to test whether parity (number of live births) predicted four previously-validated composite measures of biological age and system integrity: Levine Method, homeostatic dysregulation, Klemera–Doubal method biological age, and allostatic load. Parity exhibited a U-shaped relationship with accelerated biological aging when controlling for chronological age, lifestyle, health-related, and demographic factors in post-menopausal, but not pre-menopausal, women, with biological age acceleration being lowest among post-menopausal women reporting between three and four live births. Our findings suggest a link between reproductive function and physiological dysregulation, and allude to possible compensatory mechanisms that buffer the effects of reproductive function on physiological dysregulation during a woman’s reproductive lifespan. Future work should continue to investigate links between parity, menopausal status, and biological age using targeted physiological measures and longitudinal studies.
format	article
author	Talia N. Shirazi Waylon J. Hastings Asher Y. Rosinger Calen P. Ryan
author_facet	Talia N. Shirazi Waylon J. Hastings Asher Y. Rosinger Calen P. Ryan
author_sort	Talia N. Shirazi
title	Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
title_short	Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
title_full	Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
title_fullStr	Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
title_full_unstemmed	Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
title_sort	parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/27e4ba3472bb491a91e560cf05395dc0
work_keys_str_mv	AT talianshirazi paritypredictsbiologicalageaccelerationinpostmenopausalbutnotpremenopausalwomen AT waylonjhastings paritypredictsbiologicalageaccelerationinpostmenopausalbutnotpremenopausalwomen AT asheryrosinger paritypredictsbiologicalageaccelerationinpostmenopausalbutnotpremenopausalwomen AT calenpryan paritypredictsbiologicalageaccelerationinpostmenopausalbutnotpremenopausalwomen
_version_	1718384458227253248

Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women

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