Health monitoring in birds using bio-loggers and whole blood transcriptomics

Abstract Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-...

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Autores principales:	Elinor Jax, Inge Müller, Stefan Börno, Hanna Borlinghaus, Gustaw Eriksson, Evi Fricke, Bernd Timmermann, Helene Pendl, Wolfgang Fiedler, Karsten Klein, Falk Schreiber, Martin Wikelski, Katharine E. Magor, Robert H. S. Kraus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27e5714cad564a6ba1cc16cb555d4a58
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id	oai:doaj.org-article:27e5714cad564a6ba1cc16cb555d4a58
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spelling	oai:doaj.org-article:27e5714cad564a6ba1cc16cb555d4a582021-12-02T14:42:01ZHealth monitoring in birds using bio-loggers and whole blood transcriptomics10.1038/s41598-021-90212-82045-2322https://doaj.org/article/27e5714cad564a6ba1cc16cb555d4a582021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90212-8https://doaj.org/toc/2045-2322Abstract Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.Elinor JaxInge MüllerStefan BörnoHanna BorlinghausGustaw ErikssonEvi FrickeBernd TimmermannHelene PendlWolfgang FiedlerKarsten KleinFalk SchreiberMartin WikelskiKatharine E. MagorRobert H. S. KrausNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elinor Jax Inge Müller Stefan Börno Hanna Borlinghaus Gustaw Eriksson Evi Fricke Bernd Timmermann Helene Pendl Wolfgang Fiedler Karsten Klein Falk Schreiber Martin Wikelski Katharine E. Magor Robert H. S. Kraus Health monitoring in birds using bio-loggers and whole blood transcriptomics
description	Abstract Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.
format	article
author	Elinor Jax Inge Müller Stefan Börno Hanna Borlinghaus Gustaw Eriksson Evi Fricke Bernd Timmermann Helene Pendl Wolfgang Fiedler Karsten Klein Falk Schreiber Martin Wikelski Katharine E. Magor Robert H. S. Kraus
author_facet	Elinor Jax Inge Müller Stefan Börno Hanna Borlinghaus Gustaw Eriksson Evi Fricke Bernd Timmermann Helene Pendl Wolfgang Fiedler Karsten Klein Falk Schreiber Martin Wikelski Katharine E. Magor Robert H. S. Kraus
author_sort	Elinor Jax
title	Health monitoring in birds using bio-loggers and whole blood transcriptomics
title_short	Health monitoring in birds using bio-loggers and whole blood transcriptomics
title_full	Health monitoring in birds using bio-loggers and whole blood transcriptomics
title_fullStr	Health monitoring in birds using bio-loggers and whole blood transcriptomics
title_full_unstemmed	Health monitoring in birds using bio-loggers and whole blood transcriptomics
title_sort	health monitoring in birds using bio-loggers and whole blood transcriptomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27e5714cad564a6ba1cc16cb555d4a58
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Health monitoring in birds using bio-loggers and whole blood transcriptomics

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