Obesity, Diabetes, and Increased Cancer Progression

Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk of developing several types of cancers, including...

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Autores principales:	Dae-Seok Kim, Philipp E. Scherer
Formato:	article
Lenguaje:	EN
Publicado:	Korean Diabetes Association 2021
Materias:	adipokines adipose tissue neoplasms diabetes mellitus, type 2 hyperlipidemia insulin resistance obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/27e76c839ca846129a8ef51a3ef5116d
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id	oai:doaj.org-article:27e76c839ca846129a8ef51a3ef5116d
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spelling	oai:doaj.org-article:27e76c839ca846129a8ef51a3ef5116d2021-12-01T05:07:51ZObesity, Diabetes, and Increased Cancer Progression2233-60792233-608710.4093/dmj.2021.0077https://doaj.org/article/27e76c839ca846129a8ef51a3ef5116d2021-11-01T00:00:00Zhttp://www.e-dmj.org/upload/pdf/dmj-2021-0077.pdfhttps://doaj.org/toc/2233-6079https://doaj.org/toc/2233-6087Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk of developing several types of cancers, including liver, pancreatic, endometrial, colorectal, and post-menopausal breast cancer. The path towards developing obesity and diabetes is affected by multiple factors, including adipokines, inflammatory cytokines, growth hormones, insulin resistance, and hyperlipidemia. The metabolic abnormalities associated with changes in the levels of these factors in obesity and diabetes have the potential to significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways. Here, we highlight the cellular and molecular pathways that constitute the links between obesity, diabetes, cancer risk and mortality. This includes a description of the existing evidence supporting the obesity-driven morphological and functional alternations of cancer cells and adipocytes through complex interactions within the tumor microenvironment.Dae-Seok KimPhilipp E. SchererKorean Diabetes Associationarticleadipokinesadipose tissueneoplasmsdiabetes mellitus, type 2hyperlipidemiainsulin resistanceobesityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENDiabetes & Metabolism Journal, Vol 45, Iss 6, Pp 799-812 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipokines adipose tissue neoplasms diabetes mellitus, type 2 hyperlipidemia insulin resistance obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	adipokines adipose tissue neoplasms diabetes mellitus, type 2 hyperlipidemia insulin resistance obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Dae-Seok Kim Philipp E. Scherer Obesity, Diabetes, and Increased Cancer Progression
description	Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk of developing several types of cancers, including liver, pancreatic, endometrial, colorectal, and post-menopausal breast cancer. The path towards developing obesity and diabetes is affected by multiple factors, including adipokines, inflammatory cytokines, growth hormones, insulin resistance, and hyperlipidemia. The metabolic abnormalities associated with changes in the levels of these factors in obesity and diabetes have the potential to significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways. Here, we highlight the cellular and molecular pathways that constitute the links between obesity, diabetes, cancer risk and mortality. This includes a description of the existing evidence supporting the obesity-driven morphological and functional alternations of cancer cells and adipocytes through complex interactions within the tumor microenvironment.
format	article
author	Dae-Seok Kim Philipp E. Scherer
author_facet	Dae-Seok Kim Philipp E. Scherer
author_sort	Dae-Seok Kim
title	Obesity, Diabetes, and Increased Cancer Progression
title_short	Obesity, Diabetes, and Increased Cancer Progression
title_full	Obesity, Diabetes, and Increased Cancer Progression
title_fullStr	Obesity, Diabetes, and Increased Cancer Progression
title_full_unstemmed	Obesity, Diabetes, and Increased Cancer Progression
title_sort	obesity, diabetes, and increased cancer progression
publisher	Korean Diabetes Association
publishDate	2021
url	https://doaj.org/article/27e76c839ca846129a8ef51a3ef5116d
work_keys_str_mv	AT daeseokkim obesitydiabetesandincreasedcancerprogression AT philippescherer obesitydiabetesandincreasedcancerprogression
_version_	1718405529949175808

Obesity, Diabetes, and Increased Cancer Progression

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