Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.

<h4>Objective</h4>This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C → T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM).<h4>Research desi...

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Autores principales:	Jian-Hong Zhong, A Chapin Rodríguez, Na-Na Yang, Le-Qun Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27e80b65da20424d988bff10f5be63ac
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spelling	oai:doaj.org-article:27e80b65da20424d988bff10f5be63ac2021-11-18T08:56:51ZMethylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.1932-620310.1371/journal.pone.0074521https://doaj.org/article/27e80b65da20424d988bff10f5be63ac2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023947/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C → T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM).<h4>Research design and methods</h4>Several research databases were systematically searched for studies examining the genotype at the rs1801133 polymorphism in healthy control individuals and individuals with type 2 DM. Genotype frequency data were examined across all studies and across subsets of studies according to ethnicity and presence of serious DM-related complications. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.<h4>Results</h4>A total of 4855 individuals with type 2 DM and 5242 healthy controls from 15 countries comprising Asian, Caucasian and African ethnicities were found to satisfy the inclusion criteria and included in the review. Genotype at the rs1801133 polymorphism was not consistently associated with either increased or reduced risk of type 2 DM; the OR across all studies was 0.91 (95%CI 0.82 to 1.00) for the C- vs. T-allele, 0.88 (0.75 to 1.03) for CC vs. CT+TT, 0.82 (0.71 to 0.95) for CC vs. TT, and 1.15 (1.03 to 1.29) for TT vs. CC+CT. Similar results were found when the meta-analysis was repeated separately for each ethnic subgroup, and for subgroups with or without serious DM-related complications.<h4>Conclusions</h4>There does not appear to be compelling evidence of an association between the genotype at the rs1801133 polymorphism of the MTHFR gene and risk of type 2 DM.Jian-Hong ZhongA Chapin RodríguezNa-Na YangLe-Qun LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74521 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Hong Zhong A Chapin Rodríguez Na-Na Yang Le-Qun Li Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
description	<h4>Objective</h4>This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C → T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM).<h4>Research design and methods</h4>Several research databases were systematically searched for studies examining the genotype at the rs1801133 polymorphism in healthy control individuals and individuals with type 2 DM. Genotype frequency data were examined across all studies and across subsets of studies according to ethnicity and presence of serious DM-related complications. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.<h4>Results</h4>A total of 4855 individuals with type 2 DM and 5242 healthy controls from 15 countries comprising Asian, Caucasian and African ethnicities were found to satisfy the inclusion criteria and included in the review. Genotype at the rs1801133 polymorphism was not consistently associated with either increased or reduced risk of type 2 DM; the OR across all studies was 0.91 (95%CI 0.82 to 1.00) for the C- vs. T-allele, 0.88 (0.75 to 1.03) for CC vs. CT+TT, 0.82 (0.71 to 0.95) for CC vs. TT, and 1.15 (1.03 to 1.29) for TT vs. CC+CT. Similar results were found when the meta-analysis was repeated separately for each ethnic subgroup, and for subgroups with or without serious DM-related complications.<h4>Conclusions</h4>There does not appear to be compelling evidence of an association between the genotype at the rs1801133 polymorphism of the MTHFR gene and risk of type 2 DM.
format	article
author	Jian-Hong Zhong A Chapin Rodríguez Na-Na Yang Le-Qun Li
author_facet	Jian-Hong Zhong A Chapin Rodríguez Na-Na Yang Le-Qun Li
author_sort	Jian-Hong Zhong
title	Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
title_short	Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
title_full	Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
title_fullStr	Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
title_full_unstemmed	Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
title_sort	methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/27e80b65da20424d988bff10f5be63ac
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Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.

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