Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice

Abstract Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a ther...

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Autores principales:	Enrique Calvo, Noelia Keiran, Catalina Núñez-Roa, Elsa Maymó-Masip, Miriam Ejarque, Joan Sabadell-Basallote, María del Mar Rodríguez-Peña, Victòria Ceperuelo-Mallafré, Jesús Seco, Ester Benaiges, Theodora Michalopoulou, Rosa Jorba, Joan Vendrell, Sonia Fernández-Veledo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27e8a7169a344c70913c6bfca80e9cd0
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spelling	oai:doaj.org-article:27e8a7169a344c70913c6bfca80e9cd02021-12-02T15:39:41ZEffects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice10.1038/s41598-021-93224-62045-2322https://doaj.org/article/27e8a7169a344c70913c6bfca80e9cd02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93224-6https://doaj.org/toc/2045-2322Abstract Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.Enrique CalvoNoelia KeiranCatalina Núñez-RoaElsa Maymó-MasipMiriam EjarqueJoan Sabadell-BasalloteMaría del Mar Rodríguez-PeñaVictòria Ceperuelo-MallafréJesús SecoEster BenaigesTheodora MichalopoulouRosa JorbaJoan VendrellSonia Fernández-VeledoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrique Calvo Noelia Keiran Catalina Núñez-Roa Elsa Maymó-Masip Miriam Ejarque Joan Sabadell-Basallote María del Mar Rodríguez-Peña Victòria Ceperuelo-Mallafré Jesús Seco Ester Benaiges Theodora Michalopoulou Rosa Jorba Joan Vendrell Sonia Fernández-Veledo Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
description	Abstract Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.
format	article
author	Enrique Calvo Noelia Keiran Catalina Núñez-Roa Elsa Maymó-Masip Miriam Ejarque Joan Sabadell-Basallote María del Mar Rodríguez-Peña Victòria Ceperuelo-Mallafré Jesús Seco Ester Benaiges Theodora Michalopoulou Rosa Jorba Joan Vendrell Sonia Fernández-Veledo
author_facet	Enrique Calvo Noelia Keiran Catalina Núñez-Roa Elsa Maymó-Masip Miriam Ejarque Joan Sabadell-Basallote María del Mar Rodríguez-Peña Victòria Ceperuelo-Mallafré Jesús Seco Ester Benaiges Theodora Michalopoulou Rosa Jorba Joan Vendrell Sonia Fernández-Veledo
author_sort	Enrique Calvo
title	Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
title_short	Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
title_full	Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
title_fullStr	Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
title_full_unstemmed	Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
title_sort	effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27e8a7169a344c70913c6bfca80e9cd0
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Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice

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