Burns and biofilms: priority pathogens and in vivo models

Abstract Burn wounds can create significant damage to human skin, compromising one of the key barriers to infection. The leading cause of death among burn wound patients is infection. Even in the patients that survive, infections can be notoriously difficult to treat and can cause lasting damage, wi...

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Autores principales:	Evgenia Maslova, Lara Eisaiankhongi, Folke Sjöberg, Ronan R. McCarthy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/27eae4f32f45449185245372813faa8b
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spelling	oai:doaj.org-article:27eae4f32f45449185245372813faa8b2021-12-02T17:41:19ZBurns and biofilms: priority pathogens and in vivo models10.1038/s41522-021-00243-22055-5008https://doaj.org/article/27eae4f32f45449185245372813faa8b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00243-2https://doaj.org/toc/2055-5008Abstract Burn wounds can create significant damage to human skin, compromising one of the key barriers to infection. The leading cause of death among burn wound patients is infection. Even in the patients that survive, infections can be notoriously difficult to treat and can cause lasting damage, with delayed healing and prolonged hospital stays. Biofilm formation in the burn wound site is a major contributing factor to the failure of burn treatment regimens and mortality as a result of burn wound infection. Bacteria forming a biofilm or a bacterial community encased in a polysaccharide matrix are more resistant to disinfection, the rigors of the host immune system, and critically, more tolerant to antibiotics. Burn wound-associated biofilms are also thought to act as a launchpad for bacteria to establish deeper, systemic infection and ultimately bacteremia and sepsis. In this review, we discuss some of the leading burn wound pathogens and outline how they regulate biofilm formation in the burn wound microenvironment. We also discuss the new and emerging models that are available to study burn wound biofilm formation in vivo.Evgenia MaslovaLara EisaiankhongiFolke SjöbergRonan R. McCarthyNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Evgenia Maslova Lara Eisaiankhongi Folke Sjöberg Ronan R. McCarthy Burns and biofilms: priority pathogens and in vivo models
description	Abstract Burn wounds can create significant damage to human skin, compromising one of the key barriers to infection. The leading cause of death among burn wound patients is infection. Even in the patients that survive, infections can be notoriously difficult to treat and can cause lasting damage, with delayed healing and prolonged hospital stays. Biofilm formation in the burn wound site is a major contributing factor to the failure of burn treatment regimens and mortality as a result of burn wound infection. Bacteria forming a biofilm or a bacterial community encased in a polysaccharide matrix are more resistant to disinfection, the rigors of the host immune system, and critically, more tolerant to antibiotics. Burn wound-associated biofilms are also thought to act as a launchpad for bacteria to establish deeper, systemic infection and ultimately bacteremia and sepsis. In this review, we discuss some of the leading burn wound pathogens and outline how they regulate biofilm formation in the burn wound microenvironment. We also discuss the new and emerging models that are available to study burn wound biofilm formation in vivo.
format	article
author	Evgenia Maslova Lara Eisaiankhongi Folke Sjöberg Ronan R. McCarthy
author_facet	Evgenia Maslova Lara Eisaiankhongi Folke Sjöberg Ronan R. McCarthy
author_sort	Evgenia Maslova
title	Burns and biofilms: priority pathogens and in vivo models
title_short	Burns and biofilms: priority pathogens and in vivo models
title_full	Burns and biofilms: priority pathogens and in vivo models
title_fullStr	Burns and biofilms: priority pathogens and in vivo models
title_full_unstemmed	Burns and biofilms: priority pathogens and in vivo models
title_sort	burns and biofilms: priority pathogens and in vivo models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27eae4f32f45449185245372813faa8b
work_keys_str_mv	AT evgeniamaslova burnsandbiofilmsprioritypathogensandinvivomodels AT laraeisaiankhongi burnsandbiofilmsprioritypathogensandinvivomodels AT folkesjoberg burnsandbiofilmsprioritypathogensandinvivomodels AT ronanrmccarthy burnsandbiofilmsprioritypathogensandinvivomodels
_version_	1718379695131590656

Burns and biofilms: priority pathogens and in vivo models

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