Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation

Jeannette A Goudzwaard,1 Eleonora Disegna,1 Marjo JAG de Ronde-Tillmans,2 Mattie J Lenzen,2 Peter PT de Jaegere,2 Francesco US Mattace-Raso11Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Department of Interventional Ca...

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Autores principales:	Goudzwaard JA, Disegna E, de Ronde-Tillmans MJAG, Lenzen MJ, de Jaegere PPT, Mattace-Raso FUS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	aortic valve stenosis aortic stiffness blood pressure levels TAVI Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/27eb14d0375c4f4e873e546468e2604f
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spelling	oai:doaj.org-article:27eb14d0375c4f4e873e546468e2604f2021-12-02T09:30:14ZShort-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation1178-1998https://doaj.org/article/27eb14d0375c4f4e873e546468e2604f2019-08-01T00:00:00Zhttps://www.dovepress.com/short-term-changes-of-blood-pressure-and-aortic-stiffness-in-older-pat-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jeannette A Goudzwaard,1 Eleonora Disegna,1 Marjo JAG de Ronde-Tillmans,2 Mattie J Lenzen,2 Peter PT de Jaegere,2 Francesco US Mattace-Raso11Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the NetherlandsBackground: Both aortic valve stenosis and aortic stiffness are moderators of arterio ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of transcatheter aortic valve implantation (TAVI) on aortic functional properties are limited. We performed a study to investigate the possible short-term changes in aortic stiffness and other aortic functional properties after TAVI in older patients.Methods: TAVI Care&Cure is an observational ongoing study including consecutive patients undergoing a TAVI procedure. Central and peripheral hemodynamic measurements were measured non invasively 1 day before (T-1) and 1 day after (T+1) TAVI using a validated oscillometric method using a brachial cuff (Mobil-O-Graph).Results: 40 patients were included. Mean aortic valve area at baseline was 0.76±0.24 cm2. Indices of severity of aortic valve stenosis improved significantly. Systolic blood pressure (SBP) dropped by 8.5%, from 130.3±22.9 mmHg to 119.5±15.8 mmHg (p=0.005). Diastolic blood pressure (DBP) dropped by 13.1% from 74.8±14.5 mmHg to 65.0±11.3 mmHg (p<0.001). The arterial pulse wave velocity (aPWV) decreased from 12.05±1.99 m/s to 11.6±1.56 m/s (p=0.006). Patients with high aPWV at baseline showed a significantly larger reduction in SBP in comparison to patients with low aPWV: – 20.3 mmHg (−14.1%) vs – 3.1 mmHg (−2.6%), respectively (p=0.033). The same trend was found for the DBP: −16.2 (−20.4%) vs −4.5 mmHg (−6.3%) for high vs low aPWV at baseline (p=0.037).Conclusion: We found short-term changes in blood pressure and aortic stiffness after TAVI. The amplitude of the changes was the largest in patients with elevated aortic stiffness at baseline.Keywords: aortic valve stenosis, aortic stiffness, blood pressure levels, TAVIGoudzwaard JADisegna Ede Ronde-Tillmans MJAGLenzen MJde Jaegere PPTMattace-Raso FUSDove Medical Pressarticleaortic valve stenosisaortic stiffnessblood pressure levelsTAVIGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1379-1386 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	aortic valve stenosis aortic stiffness blood pressure levels TAVI Geriatrics RC952-954.6
spellingShingle	aortic valve stenosis aortic stiffness blood pressure levels TAVI Geriatrics RC952-954.6 Goudzwaard JA Disegna E de Ronde-Tillmans MJAG Lenzen MJ de Jaegere PPT Mattace-Raso FUS Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
description	Jeannette A Goudzwaard,1 Eleonora Disegna,1 Marjo JAG de Ronde-Tillmans,2 Mattie J Lenzen,2 Peter PT de Jaegere,2 Francesco US Mattace-Raso11Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the NetherlandsBackground: Both aortic valve stenosis and aortic stiffness are moderators of arterio ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of transcatheter aortic valve implantation (TAVI) on aortic functional properties are limited. We performed a study to investigate the possible short-term changes in aortic stiffness and other aortic functional properties after TAVI in older patients.Methods: TAVI Care&Cure is an observational ongoing study including consecutive patients undergoing a TAVI procedure. Central and peripheral hemodynamic measurements were measured non invasively 1 day before (T-1) and 1 day after (T+1) TAVI using a validated oscillometric method using a brachial cuff (Mobil-O-Graph).Results: 40 patients were included. Mean aortic valve area at baseline was 0.76±0.24 cm2. Indices of severity of aortic valve stenosis improved significantly. Systolic blood pressure (SBP) dropped by 8.5%, from 130.3±22.9 mmHg to 119.5±15.8 mmHg (p=0.005). Diastolic blood pressure (DBP) dropped by 13.1% from 74.8±14.5 mmHg to 65.0±11.3 mmHg (p<0.001). The arterial pulse wave velocity (aPWV) decreased from 12.05±1.99 m/s to 11.6±1.56 m/s (p=0.006). Patients with high aPWV at baseline showed a significantly larger reduction in SBP in comparison to patients with low aPWV: – 20.3 mmHg (−14.1%) vs – 3.1 mmHg (−2.6%), respectively (p=0.033). The same trend was found for the DBP: −16.2 (−20.4%) vs −4.5 mmHg (−6.3%) for high vs low aPWV at baseline (p=0.037).Conclusion: We found short-term changes in blood pressure and aortic stiffness after TAVI. The amplitude of the changes was the largest in patients with elevated aortic stiffness at baseline.Keywords: aortic valve stenosis, aortic stiffness, blood pressure levels, TAVI
format	article
author	Goudzwaard JA Disegna E de Ronde-Tillmans MJAG Lenzen MJ de Jaegere PPT Mattace-Raso FUS
author_facet	Goudzwaard JA Disegna E de Ronde-Tillmans MJAG Lenzen MJ de Jaegere PPT Mattace-Raso FUS
author_sort	Goudzwaard JA
title	Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
title_short	Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
title_full	Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
title_fullStr	Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
title_full_unstemmed	Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
title_sort	short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/27eb14d0375c4f4e873e546468e2604f
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Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation

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