Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

Mahmoud A Allam,1 Youssef A Nassar,1 Hosameldeen S Shabana,1 Sadek Mostafa,1 Farag Khalil,1 Hendawy Zidan,1 Mohammed Abo-Ghebsha,2 Amir Abdelghaffar,3 Ahmed Essmat,3 Essam Elmahdi4 1Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Clinical Patho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Allam MA, Nassar YA, Shabana HS, Mostafa S, Khalil F, Zidan H, Abo-Ghebsha M, Abdelghaffar A, Essmat A, Elmahdi E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetes mellitus diabetic peripheral neuropathy subclinical hypothyroidism thyroid hormones thyroid dysfunction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/27f00aefd83343c0a27937705bcf4ef9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:27f00aefd83343c0a27937705bcf4ef9
record_format	dspace
spelling	oai:doaj.org-article:27f00aefd83343c0a27937705bcf4ef92021-11-07T18:42:56ZPrevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy1178-7074https://doaj.org/article/27f00aefd83343c0a27937705bcf4ef92021-11-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-clinical-significance-of-subclinical-hypothyroidism-in--peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Mahmoud A Allam,1 Youssef A Nassar,1 Hosameldeen S Shabana,1 Sadek Mostafa,1 Farag Khalil,1 Hendawy Zidan,1 Mohammed Abo-Ghebsha,2 Amir Abdelghaffar,3 Ahmed Essmat,3 Essam Elmahdi4 1Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3Department of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, EgyptCorrespondence: Mahmoud A AllamDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, 11884, EgyptTel +20222602687Fax +20224020184Email dr.mahmoudallam75@gmail.comBackground and Aim: Diabetic peripheral neuropathy (DPN) is one of the most common and disabling complications of DM. Many studies documented the prevalence of clinical and subclinical hypothyroidism (SCH) in diabetic patients but not in the particular group of patients with DPN. The present study aimed to determine the prevalence of SCH in DPN patients and to evaluate its association with severity of DPN.Patients and Methods: The present cross-sectional study was conducted on 300 consecutive patients with DPN. The clinical manifestations of DPN were documented according to the validated Arabic version of the Michigan Neuropathy Screening Instrument. Severity of DPN was categorized into mild (6– 8 points), moderate (9– 11 points) or severe (12+ points) according to the Toronto Clinical Scoring System. All patients were submitted to careful history-taking and full clinical and neurological examination. Patients were diagnosed with SCH if they had TSH level above the upper limit of the normal reference range in association with normal free thyroxine (FT4) level.Results: SCH was prevalent in 53 patients (17.7%, 95% CI: 13.5%– 22.5%). Patients with SCH had significantly higher frequency of severe DPN (52.8% versus 28.3%, p=0.003). It was also shown that patients with SCH had significantly higher HbA1c (8.4 ± 1.0 versus 7.3 ± 1.2%, p< 0.001) and HOMA-IR (3.7 ± 0.8 versus 2.7 ± 0.9, p< 0.001) when compared with patients without SCH. Logistic regression analysis identified patients’ age [OR (95% CI): 1.06 (1.03– 1.08), p< 0.001], HbA1c [OR (95% CI): 2.2 (1.7– 2.9), p< 0.001] and SCH [OR (95% CI): 7.7 (3.6– 15.5), p< 0.001] as independent predictors of DPN severity.Conclusion: The present study showed that SCH is highly prevalent in DPN patients and is independently related to its severity.Keywords: diabetes mellitus, diabetic peripheral neuropathy, subclinical hypothyroidism, thyroid hormones, thyroid dysfunctionAllam MANassar YAShabana HSMostafa SKhalil FZidan HAbo-Ghebsha MAbdelghaffar AEssmat AElmahdi EDove Medical Pressarticlediabetes mellitusdiabetic peripheral neuropathysubclinical hypothyroidismthyroid hormonesthyroid dysfunctionMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 7755-7761 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus diabetic peripheral neuropathy subclinical hypothyroidism thyroid hormones thyroid dysfunction Medicine (General) R5-920
spellingShingle	diabetes mellitus diabetic peripheral neuropathy subclinical hypothyroidism thyroid hormones thyroid dysfunction Medicine (General) R5-920 Allam MA Nassar YA Shabana HS Mostafa S Khalil F Zidan H Abo-Ghebsha M Abdelghaffar A Essmat A Elmahdi E Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy
description	Mahmoud A Allam,1 Youssef A Nassar,1 Hosameldeen S Shabana,1 Sadek Mostafa,1 Farag Khalil,1 Hendawy Zidan,1 Mohammed Abo-Ghebsha,2 Amir Abdelghaffar,3 Ahmed Essmat,3 Essam Elmahdi4 1Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3Department of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, EgyptCorrespondence: Mahmoud A AllamDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, 11884, EgyptTel +20222602687Fax +20224020184Email dr.mahmoudallam75@gmail.comBackground and Aim: Diabetic peripheral neuropathy (DPN) is one of the most common and disabling complications of DM. Many studies documented the prevalence of clinical and subclinical hypothyroidism (SCH) in diabetic patients but not in the particular group of patients with DPN. The present study aimed to determine the prevalence of SCH in DPN patients and to evaluate its association with severity of DPN.Patients and Methods: The present cross-sectional study was conducted on 300 consecutive patients with DPN. The clinical manifestations of DPN were documented according to the validated Arabic version of the Michigan Neuropathy Screening Instrument. Severity of DPN was categorized into mild (6– 8 points), moderate (9– 11 points) or severe (12+ points) according to the Toronto Clinical Scoring System. All patients were submitted to careful history-taking and full clinical and neurological examination. Patients were diagnosed with SCH if they had TSH level above the upper limit of the normal reference range in association with normal free thyroxine (FT4) level.Results: SCH was prevalent in 53 patients (17.7%, 95% CI: 13.5%– 22.5%). Patients with SCH had significantly higher frequency of severe DPN (52.8% versus 28.3%, p=0.003). It was also shown that patients with SCH had significantly higher HbA1c (8.4 ± 1.0 versus 7.3 ± 1.2%, p< 0.001) and HOMA-IR (3.7 ± 0.8 versus 2.7 ± 0.9, p< 0.001) when compared with patients without SCH. Logistic regression analysis identified patients’ age [OR (95% CI): 1.06 (1.03– 1.08), p< 0.001], HbA1c [OR (95% CI): 2.2 (1.7– 2.9), p< 0.001] and SCH [OR (95% CI): 7.7 (3.6– 15.5), p< 0.001] as independent predictors of DPN severity.Conclusion: The present study showed that SCH is highly prevalent in DPN patients and is independently related to its severity.Keywords: diabetes mellitus, diabetic peripheral neuropathy, subclinical hypothyroidism, thyroid hormones, thyroid dysfunction
format	article
author	Allam MA Nassar YA Shabana HS Mostafa S Khalil F Zidan H Abo-Ghebsha M Abdelghaffar A Essmat A Elmahdi E
author_facet	Allam MA Nassar YA Shabana HS Mostafa S Khalil F Zidan H Abo-Ghebsha M Abdelghaffar A Essmat A Elmahdi E
author_sort	Allam MA
title	Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy
title_short	Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy
title_full	Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy
title_fullStr	Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy
title_full_unstemmed	Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy
title_sort	prevalence and clinical significance of subclinical hypothyroidism in diabetic peripheral neuropathy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/27f00aefd83343c0a27937705bcf4ef9
work_keys_str_mv	AT allamma prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT nassarya prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT shabanahs prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT mostafas prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT khalilf prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT zidanh prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT aboghebsham prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT abdelghaffara prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT essmata prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy AT elmahdie prevalenceandclinicalsignificanceofsubclinicalhypothyroidismindiabeticperipheralneuropathy
_version_	1718443265231945728

Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

Ejemplares similares