Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections

Darlene MillerAbrams Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, Anne Bates Leach Eye Hospital, Miller School of Medicine-University of Miami, FL, USAAbstract: Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox&reg;) is the ocular formulation/adaptation of moxiflox...

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Autor principal:	Darlene Miller
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/27f0409c06d14c9aa987cc8fbc19de12
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spelling	oai:doaj.org-article:27f0409c06d14c9aa987cc8fbc19de122021-12-02T00:29:22ZReview of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections1177-54671177-5483https://doaj.org/article/27f0409c06d14c9aa987cc8fbc19de122008-03-01T00:00:00Zhttp://www.dovepress.com/review-of-moxifloxacin-hydrochloride-ophthalmic-solution-in-the-treatm-a364https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Darlene MillerAbrams Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, Anne Bates Leach Eye Hospital, Miller School of Medicine-University of Miami, FL, USAAbstract: Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox&reg;) is the ocular formulation/adaptation of moxifloxacin. Moxifloxacin is a broad spectrum 8-methoxyfluoroquinolone which terminates bacterial growth by binding to DNA gyrase (topoisomerase II) and topoisomerase IV, essential bacterial enzymes involved in the replication, translation, repair and recombination of deoxyribonucleic acid. Affinity for both enzymes improves potency and reduces the probability of selecting resistant bacterial subpopulations. Vigamox is a bactericidal, concentration dependent, anti-infective. It is preservative free, and well tolerated with minimal ocular side effects. It provides increased penetration into ocular tissues and fluids with improved activity against Streptococci and Staphylococci species and moderate to excellent activity against clinically relevant, gram- negative ocular pathogens.Keywords: moxifloxacin, vigamox, pharmacodynamic indices, minimal inhibitory concentrations Darlene MillerDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 1, Pp 77-91 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Darlene Miller Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
description	Darlene MillerAbrams Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, Anne Bates Leach Eye Hospital, Miller School of Medicine-University of Miami, FL, USAAbstract: Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox&reg;) is the ocular formulation/adaptation of moxifloxacin. Moxifloxacin is a broad spectrum 8-methoxyfluoroquinolone which terminates bacterial growth by binding to DNA gyrase (topoisomerase II) and topoisomerase IV, essential bacterial enzymes involved in the replication, translation, repair and recombination of deoxyribonucleic acid. Affinity for both enzymes improves potency and reduces the probability of selecting resistant bacterial subpopulations. Vigamox is a bactericidal, concentration dependent, anti-infective. It is preservative free, and well tolerated with minimal ocular side effects. It provides increased penetration into ocular tissues and fluids with improved activity against Streptococci and Staphylococci species and moderate to excellent activity against clinically relevant, gram- negative ocular pathogens.Keywords: moxifloxacin, vigamox, pharmacodynamic indices, minimal inhibitory concentrations
format	article
author	Darlene Miller
author_facet	Darlene Miller
author_sort	Darlene Miller
title	Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
title_short	Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
title_full	Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
title_fullStr	Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
title_full_unstemmed	Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
title_sort	review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/27f0409c06d14c9aa987cc8fbc19de12
work_keys_str_mv	AT darlenemiller reviewofmoxifloxacinhydrochlorideophthalmicsolutioninthetreatmentofbacterialeyeinfections
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Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections

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