Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut

ABSTRACT Many factors shape the ability of different microbes to coexist in microbial communities. In the human gut, dietary and host-derived nutrients largely drive microbial community structure. How gut microbes with very similar nutrient profiles are able to coexist over time within the same host...

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Autor principal:	Petra Louis
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Bacteroides community diversity competition glycan microbiota Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/27f1251ffa244c128860ba9bfcb3f7bc
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spelling	oai:doaj.org-article:27f1251ffa244c128860ba9bfcb3f7bc2021-11-15T15:51:56ZDifferent Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut10.1128/mBio.01824-172150-7511https://doaj.org/article/27f1251ffa244c128860ba9bfcb3f7bc2017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01824-17https://doaj.org/toc/2150-7511ABSTRACT Many factors shape the ability of different microbes to coexist in microbial communities. In the human gut, dietary and host-derived nutrients largely drive microbial community structure. How gut microbes with very similar nutrient profiles are able to coexist over time within the same host is not fully understood. Tuncil et al. (mBio 8:e01068-17, 2017, https://doi.org/10.1128/mBio.01068-17 ) explored glycan prioritization in two closely related human gut bacteria, Bacteroides ovatus and Bacteroides thetaiotaomicron, on complex glycan mixtures that both organisms can degrade. Determining depletion of the individual glycans over time in pure cultures and cocultures revealed that the bacteria seem to have hardwired differences in their preferences for different glycans which likely contribute to their stable coexistence. The researchers also established that gene expression changes of the corresponding polysaccharide utilization loci did not always mirror glycan depletion, which highlights that additional regulatory mechanisms must be present.Petra LouisAmerican Society for MicrobiologyarticleBacteroidescommunity diversitycompetitionglycanmicrobiotaMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bacteroides community diversity competition glycan microbiota Microbiology QR1-502
spellingShingle	Bacteroides community diversity competition glycan microbiota Microbiology QR1-502 Petra Louis Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut
description	ABSTRACT Many factors shape the ability of different microbes to coexist in microbial communities. In the human gut, dietary and host-derived nutrients largely drive microbial community structure. How gut microbes with very similar nutrient profiles are able to coexist over time within the same host is not fully understood. Tuncil et al. (mBio 8:e01068-17, 2017, https://doi.org/10.1128/mBio.01068-17 ) explored glycan prioritization in two closely related human gut bacteria, Bacteroides ovatus and Bacteroides thetaiotaomicron, on complex glycan mixtures that both organisms can degrade. Determining depletion of the individual glycans over time in pure cultures and cocultures revealed that the bacteria seem to have hardwired differences in their preferences for different glycans which likely contribute to their stable coexistence. The researchers also established that gene expression changes of the corresponding polysaccharide utilization loci did not always mirror glycan depletion, which highlights that additional regulatory mechanisms must be present.
format	article
author	Petra Louis
author_facet	Petra Louis
author_sort	Petra Louis
title	Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut
title_short	Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut
title_full	Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut
title_fullStr	Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut
title_full_unstemmed	Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut
title_sort	different substrate preferences help closely related bacteria to coexist in the gut
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/27f1251ffa244c128860ba9bfcb3f7bc
work_keys_str_mv	AT petralouis differentsubstratepreferenceshelpcloselyrelatedbacteriatocoexistinthegut
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Different Substrate Preferences Help Closely Related Bacteria To Coexist in the Gut

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