Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy with a poor prognosis. Here, the authors investigate the genomic landscape, gene expression profiles and functional mechanisms in 111 patients, highlighting TCL1 overexpression and ATM aberrations as core lesions which co-operate to impair...

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Autores principales: A. Schrader, G. Crispatzu, S. Oberbeck, P. Mayer, S. Pützer, J. von Jan, E. Vasyutina, K. Warner, N. Weit, N. Pflug, T. Braun, E. I. Andersson, B. Yadav, A. Riabinska, B. Maurer, M. S. Ventura Ferreira, F. Beier, J. Altmüller, M. Lanasa, C. D. Herling, T. Haferlach, S. Stilgenbauer, G. Hopfinger, M. Peifer, T. H. Brümmendorf, P. Nürnberg, K. S. J. Elenitoba-Johnson, S. Zha, M. Hallek, R. Moriggl, H. C. Reinhardt, M.-H. Stern, S. Mustjoki, S. Newrzela, P. Frommolt, M. Herling
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/27f303840c0c4d6e8ca4ef99b0371076
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spelling oai:doaj.org-article:27f303840c0c4d6e8ca4ef99b03710762021-12-02T14:39:06ZActionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL10.1038/s41467-017-02688-62041-1723https://doaj.org/article/27f303840c0c4d6e8ca4ef99b03710762018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02688-6https://doaj.org/toc/2041-1723T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy with a poor prognosis. Here, the authors investigate the genomic landscape, gene expression profiles and functional mechanisms in 111 patients, highlighting TCL1 overexpression and ATM aberrations as core lesions which co-operate to impair DNA damage processing.A. SchraderG. CrispatzuS. OberbeckP. MayerS. PützerJ. von JanE. VasyutinaK. WarnerN. WeitN. PflugT. BraunE. I. AnderssonB. YadavA. RiabinskaB. MaurerM. S. Ventura FerreiraF. BeierJ. AltmüllerM. LanasaC. D. HerlingT. HaferlachS. StilgenbauerG. HopfingerM. PeiferT. H. BrümmendorfP. NürnbergK. S. J. Elenitoba-JohnsonS. ZhaM. HallekR. MorigglH. C. ReinhardtM.-H. SternS. MustjokiS. NewrzelaP. FrommoltM. HerlingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-22 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. Schrader
G. Crispatzu
S. Oberbeck
P. Mayer
S. Pützer
J. von Jan
E. Vasyutina
K. Warner
N. Weit
N. Pflug
T. Braun
E. I. Andersson
B. Yadav
A. Riabinska
B. Maurer
M. S. Ventura Ferreira
F. Beier
J. Altmüller
M. Lanasa
C. D. Herling
T. Haferlach
S. Stilgenbauer
G. Hopfinger
M. Peifer
T. H. Brümmendorf
P. Nürnberg
K. S. J. Elenitoba-Johnson
S. Zha
M. Hallek
R. Moriggl
H. C. Reinhardt
M.-H. Stern
S. Mustjoki
S. Newrzela
P. Frommolt
M. Herling
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
description T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy with a poor prognosis. Here, the authors investigate the genomic landscape, gene expression profiles and functional mechanisms in 111 patients, highlighting TCL1 overexpression and ATM aberrations as core lesions which co-operate to impair DNA damage processing.
format article
author A. Schrader
G. Crispatzu
S. Oberbeck
P. Mayer
S. Pützer
J. von Jan
E. Vasyutina
K. Warner
N. Weit
N. Pflug
T. Braun
E. I. Andersson
B. Yadav
A. Riabinska
B. Maurer
M. S. Ventura Ferreira
F. Beier
J. Altmüller
M. Lanasa
C. D. Herling
T. Haferlach
S. Stilgenbauer
G. Hopfinger
M. Peifer
T. H. Brümmendorf
P. Nürnberg
K. S. J. Elenitoba-Johnson
S. Zha
M. Hallek
R. Moriggl
H. C. Reinhardt
M.-H. Stern
S. Mustjoki
S. Newrzela
P. Frommolt
M. Herling
author_facet A. Schrader
G. Crispatzu
S. Oberbeck
P. Mayer
S. Pützer
J. von Jan
E. Vasyutina
K. Warner
N. Weit
N. Pflug
T. Braun
E. I. Andersson
B. Yadav
A. Riabinska
B. Maurer
M. S. Ventura Ferreira
F. Beier
J. Altmüller
M. Lanasa
C. D. Herling
T. Haferlach
S. Stilgenbauer
G. Hopfinger
M. Peifer
T. H. Brümmendorf
P. Nürnberg
K. S. J. Elenitoba-Johnson
S. Zha
M. Hallek
R. Moriggl
H. C. Reinhardt
M.-H. Stern
S. Mustjoki
S. Newrzela
P. Frommolt
M. Herling
author_sort A. Schrader
title Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
title_short Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
title_full Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
title_fullStr Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
title_full_unstemmed Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
title_sort actionable perturbations of damage responses by tcl1/atm and epigenetic lesions form the basis of t-pll
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/27f303840c0c4d6e8ca4ef99b0371076
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