Medical Applications of Metallic Bismuth Nanoparticles

Recent reviews described the efficient syntheses of metallic bismuth nanoparticles. Nevertheless, few studies have been published on the medical applications of these nanoparticles compared to the number of studies on the well-documented clinical use of the bismuth(III) complex. An analysis of the l...

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Autores principales:	Catherine Gomez, Gauthier Hallot, Sophie Laurent, Marc Port
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bismuth nanoparticles theranostic agents biocompatibility Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/27f38cfa00ca4588939bd5d3a4b59970
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spelling	oai:doaj.org-article:27f38cfa00ca4588939bd5d3a4b599702021-11-25T18:40:43ZMedical Applications of Metallic Bismuth Nanoparticles10.3390/pharmaceutics131117931999-4923https://doaj.org/article/27f38cfa00ca4588939bd5d3a4b599702021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1793https://doaj.org/toc/1999-4923Recent reviews described the efficient syntheses of metallic bismuth nanoparticles. Nevertheless, few studies have been published on the medical applications of these nanoparticles compared to the number of studies on the well-documented clinical use of the bismuth(III) complex. An analysis of the literature revealed the significant potential of metallic bismuth nanoparticles in different theranostic applications. In the diagnostic field, preclinical proofs of concept have been demonstrated for X-ray, photoacoustic and fluorescence imaging. In the therapeutic field, several preclinical studies have shown the potential of bismuth nanoparticles as X-ray radiosensitizers for use in radiotherapy and as photothermal agents for applications in near infrared phototherapy. The properties of these metallic bismuth nanoparticles as bactericidal, fungicidal, antiparasitic and antibiofilm agents have also been studied. Although information concerning the toxic effects of these nanoparticles has been collected, these data are insufficient when considering the immediate clinical use of these new nanoparticles.Catherine GomezGauthier HallotSophie LaurentMarc PortMDPI AGarticlebismuthnanoparticlestheranostic agentsbiocompatibilityPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1793, p 1793 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bismuth nanoparticles theranostic agents biocompatibility Pharmacy and materia medica RS1-441
spellingShingle	bismuth nanoparticles theranostic agents biocompatibility Pharmacy and materia medica RS1-441 Catherine Gomez Gauthier Hallot Sophie Laurent Marc Port Medical Applications of Metallic Bismuth Nanoparticles
description	Recent reviews described the efficient syntheses of metallic bismuth nanoparticles. Nevertheless, few studies have been published on the medical applications of these nanoparticles compared to the number of studies on the well-documented clinical use of the bismuth(III) complex. An analysis of the literature revealed the significant potential of metallic bismuth nanoparticles in different theranostic applications. In the diagnostic field, preclinical proofs of concept have been demonstrated for X-ray, photoacoustic and fluorescence imaging. In the therapeutic field, several preclinical studies have shown the potential of bismuth nanoparticles as X-ray radiosensitizers for use in radiotherapy and as photothermal agents for applications in near infrared phototherapy. The properties of these metallic bismuth nanoparticles as bactericidal, fungicidal, antiparasitic and antibiofilm agents have also been studied. Although information concerning the toxic effects of these nanoparticles has been collected, these data are insufficient when considering the immediate clinical use of these new nanoparticles.
format	article
author	Catherine Gomez Gauthier Hallot Sophie Laurent Marc Port
author_facet	Catherine Gomez Gauthier Hallot Sophie Laurent Marc Port
author_sort	Catherine Gomez
title	Medical Applications of Metallic Bismuth Nanoparticles
title_short	Medical Applications of Metallic Bismuth Nanoparticles
title_full	Medical Applications of Metallic Bismuth Nanoparticles
title_fullStr	Medical Applications of Metallic Bismuth Nanoparticles
title_full_unstemmed	Medical Applications of Metallic Bismuth Nanoparticles
title_sort	medical applications of metallic bismuth nanoparticles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/27f38cfa00ca4588939bd5d3a4b59970
work_keys_str_mv	AT catherinegomez medicalapplicationsofmetallicbismuthnanoparticles AT gauthierhallot medicalapplicationsofmetallicbismuthnanoparticles AT sophielaurent medicalapplicationsofmetallicbismuthnanoparticles AT marcport medicalapplicationsofmetallicbismuthnanoparticles
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Medical Applications of Metallic Bismuth Nanoparticles

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