EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>

In this study the bioactivity of the fractions obtained from the ethanolic extracts of the leaves, of the trunk bark and of the root bark of Rollinia rufinervis (Annonaceae) is evaluated. It is found that they show cytotoxic activity and that the presence of acetogenins can cause the antiparasita...

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Autores principales:	Jorge E. HERNÁNDEZ C., José L. TENORIO V., Claudia M. ROJAS, Gustavo A. VALLEJO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Annonaceae Rollinia acetogenins leishmaniasis ß-sitosterol Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/27fa6e22aa284568be1aeb3d5a1e5978
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spelling	oai:doaj.org-article:27fa6e22aa284568be1aeb3d5a1e59782021-11-19T04:22:57ZEVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>0121-40042145-2660https://doaj.org/article/27fa6e22aa284568be1aeb3d5a1e59782009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/495https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 In this study the bioactivity of the fractions obtained from the ethanolic extracts of the leaves, of the trunk bark and of the root bark of Rollinia rufinervis (Annonaceae) is evaluated. It is found that they show cytotoxic activity and that the presence of acetogenins can cause the antiparasitaire activity. The fractions are tested at concentration between 0.095 μg/mL and 100 μg/mL against promastigotes of Leishmania chagasi, evaluating the parasite mobility after 72 hours. The effect of the fractions is contrasted with the mediun Schneider- Drosofila without extract and with glucantimeR, used as control. The Rollinia rufinervis fractions of: ethyl acetate of the root, petroleum ether of the bark, ethyl acetate of the bark and ethyl acetate of the leaves present leishmanicidal activity. The last fraction has the largest activity causing appreciable or total immobility of the parasites during the experiment. Probably s-sitosterol is isolated from this fraction. Jorge E. HERNÁNDEZ C.José L. TENORIO V.Claudia M. ROJASGustavo A. VALLEJOUniversidad de AntioquiaarticleAnnonaceaeRolliniaacetogeninsleishmaniasisß-sitosterolFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 12, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Annonaceae Rollinia acetogenins leishmaniasis ß-sitosterol Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Annonaceae Rollinia acetogenins leishmaniasis ß-sitosterol Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Jorge E. HERNÁNDEZ C. José L. TENORIO V. Claudia M. ROJAS Gustavo A. VALLEJO EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>
description	In this study the bioactivity of the fractions obtained from the ethanolic extracts of the leaves, of the trunk bark and of the root bark of Rollinia rufinervis (Annonaceae) is evaluated. It is found that they show cytotoxic activity and that the presence of acetogenins can cause the antiparasitaire activity. The fractions are tested at concentration between 0.095 μg/mL and 100 μg/mL against promastigotes of Leishmania chagasi, evaluating the parasite mobility after 72 hours. The effect of the fractions is contrasted with the mediun Schneider- Drosofila without extract and with glucantimeR, used as control. The Rollinia rufinervis fractions of: ethyl acetate of the root, petroleum ether of the bark, ethyl acetate of the bark and ethyl acetate of the leaves present leishmanicidal activity. The last fraction has the largest activity causing appreciable or total immobility of the parasites during the experiment. Probably s-sitosterol is isolated from this fraction.
format	article
author	Jorge E. HERNÁNDEZ C. José L. TENORIO V. Claudia M. ROJAS Gustavo A. VALLEJO
author_facet	Jorge E. HERNÁNDEZ C. José L. TENORIO V. Claudia M. ROJAS Gustavo A. VALLEJO
author_sort	Jorge E. HERNÁNDEZ C.
title	EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>
title_short	EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>
title_full	EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>
title_fullStr	EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>
title_full_unstemmed	EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>
title_sort	evaluation of the leishmanicidal activity of the ethanolic extracts of rollinia rufinervis on <i>leishmania chagasi</i>
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/27fa6e22aa284568be1aeb3d5a1e5978
work_keys_str_mv	AT jorgeehernandezc evaluationoftheleishmanicidalactivityoftheethanolicextractsofrolliniarufinervisonileishmaniachagasii AT joseltenoriov evaluationoftheleishmanicidalactivityoftheethanolicextractsofrolliniarufinervisonileishmaniachagasii AT claudiamrojas evaluationoftheleishmanicidalactivityoftheethanolicextractsofrolliniarufinervisonileishmaniachagasii AT gustavoavallejo evaluationoftheleishmanicidalactivityoftheethanolicextractsofrolliniarufinervisonileishmaniachagasii
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EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF THE ETHANOLIC EXTRACTS OF Rollinia rufinervis ON <I>Leishmania chagasi</I>

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