Specimen Collection for Translational Studies in Hidradenitis Suppurativa
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/27fb34359d0347e29f965a556a65ef3c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:27fb34359d0347e29f965a556a65ef3c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:27fb34359d0347e29f965a556a65ef3c2021-12-02T15:09:14ZSpecimen Collection for Translational Studies in Hidradenitis Suppurativa10.1038/s41598-019-48226-w2045-2322https://doaj.org/article/27fb34359d0347e29f965a556a65ef3c2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48226-whttps://doaj.org/toc/2045-2322Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.A. S. ByrdY. DinaU. J. OkohQ. Q. QuarteyC. Carmona-RiveraD. W. WilliamsM. L. KernsR. J. MillerL. PetukhovaH. B. NaikL. A. BarnesW. D. ShipmanJ. A. CaffreyJ. M. SacksS. M. MilnerO. AliuK. P. BroderickD. KimH. LiuC. A. DillenR. AhnJ. W. FrewM. J. KaplanS. KangL. A. GarzaL. S. MillerA. AlaviM. A. LowesG. A. OkoyeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q A. S. Byrd Y. Dina U. J. Okoh Q. Q. Quartey C. Carmona-Rivera D. W. Williams M. L. Kerns R. J. Miller L. Petukhova H. B. Naik L. A. Barnes W. D. Shipman J. A. Caffrey J. M. Sacks S. M. Milner O. Aliu K. P. Broderick D. Kim H. Liu C. A. Dillen R. Ahn J. W. Frew M. J. Kaplan S. Kang L. A. Garza L. S. Miller A. Alavi M. A. Lowes G. A. Okoye Specimen Collection for Translational Studies in Hidradenitis Suppurativa |
| description |
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases. |
| format |
article |
| author |
A. S. Byrd Y. Dina U. J. Okoh Q. Q. Quartey C. Carmona-Rivera D. W. Williams M. L. Kerns R. J. Miller L. Petukhova H. B. Naik L. A. Barnes W. D. Shipman J. A. Caffrey J. M. Sacks S. M. Milner O. Aliu K. P. Broderick D. Kim H. Liu C. A. Dillen R. Ahn J. W. Frew M. J. Kaplan S. Kang L. A. Garza L. S. Miller A. Alavi M. A. Lowes G. A. Okoye |
| author_facet |
A. S. Byrd Y. Dina U. J. Okoh Q. Q. Quartey C. Carmona-Rivera D. W. Williams M. L. Kerns R. J. Miller L. Petukhova H. B. Naik L. A. Barnes W. D. Shipman J. A. Caffrey J. M. Sacks S. M. Milner O. Aliu K. P. Broderick D. Kim H. Liu C. A. Dillen R. Ahn J. W. Frew M. J. Kaplan S. Kang L. A. Garza L. S. Miller A. Alavi M. A. Lowes G. A. Okoye |
| author_sort |
A. S. Byrd |
| title |
Specimen Collection for Translational Studies in Hidradenitis Suppurativa |
| title_short |
Specimen Collection for Translational Studies in Hidradenitis Suppurativa |
| title_full |
Specimen Collection for Translational Studies in Hidradenitis Suppurativa |
| title_fullStr |
Specimen Collection for Translational Studies in Hidradenitis Suppurativa |
| title_full_unstemmed |
Specimen Collection for Translational Studies in Hidradenitis Suppurativa |
| title_sort |
specimen collection for translational studies in hidradenitis suppurativa |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/27fb34359d0347e29f965a556a65ef3c |
| work_keys_str_mv |
AT asbyrd specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT ydina specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT ujokoh specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT qqquartey specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT ccarmonarivera specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT dwwilliams specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT mlkerns specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT rjmiller specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT lpetukhova specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT hbnaik specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT labarnes specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT wdshipman specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT jacaffrey specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT jmsacks specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT smmilner specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT oaliu specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT kpbroderick specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT dkim specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT hliu specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT cadillen specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT rahn specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT jwfrew specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT mjkaplan specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT skang specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT lagarza specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT lsmiller specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT aalavi specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT malowes specimencollectionfortranslationalstudiesinhidradenitissuppurativa AT gaokoye specimencollectionfortranslationalstudiesinhidradenitissuppurativa |
| _version_ |
1718387862447063040 |