Plasticity in D1-like receptor expression is associated with different components of cognitive processes.

Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-tim...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christina Herold, Illah Joshi, Omar Chehadi, Michael Hollmann, Onur Güntürkün
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27fc4cff37864a2aafd65d3359d1b6b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:27fc4cff37864a2aafd65d3359d1b6b6
record_format	dspace
spelling	oai:doaj.org-article:27fc4cff37864a2aafd65d3359d1b6b62021-11-18T07:19:37ZPlasticity in D1-like receptor expression is associated with different components of cognitive processes.1932-620310.1371/journal.pone.0036484https://doaj.org/article/27fc4cff37864a2aafd65d3359d1b6b62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22574169/?tool=EBIhttps://doaj.org/toc/1932-6203Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that accompany training of isolated cognitive subfunctions. In birds, the D1-like receptor family is extended and consists of the D1A, D1B, and D1D receptors. Our data show that D1B receptor plasticity follows a training that includes active mental maintenance of information, whereas D1A and D1D receptor plasticity in addition accompanies learning of stimulus-response associations. Plasticity of D1-like receptors plays no role for processes like response selection and stimulus discrimination. None of the tasks altered D2 receptor expression. Our study shows that different cognitive components of working memory training have distinguishable effects on D1-like receptor expression.Christina HeroldIllah JoshiOmar ChehadiMichael HollmannOnur GüntürkünPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36484 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Herold Illah Joshi Omar Chehadi Michael Hollmann Onur Güntürkün Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
description	Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that accompany training of isolated cognitive subfunctions. In birds, the D1-like receptor family is extended and consists of the D1A, D1B, and D1D receptors. Our data show that D1B receptor plasticity follows a training that includes active mental maintenance of information, whereas D1A and D1D receptor plasticity in addition accompanies learning of stimulus-response associations. Plasticity of D1-like receptors plays no role for processes like response selection and stimulus discrimination. None of the tasks altered D2 receptor expression. Our study shows that different cognitive components of working memory training have distinguishable effects on D1-like receptor expression.
format	article
author	Christina Herold Illah Joshi Omar Chehadi Michael Hollmann Onur Güntürkün
author_facet	Christina Herold Illah Joshi Omar Chehadi Michael Hollmann Onur Güntürkün
author_sort	Christina Herold
title	Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
title_short	Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
title_full	Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
title_fullStr	Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
title_full_unstemmed	Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
title_sort	plasticity in d1-like receptor expression is associated with different components of cognitive processes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/27fc4cff37864a2aafd65d3359d1b6b6
work_keys_str_mv	AT christinaherold plasticityind1likereceptorexpressionisassociatedwithdifferentcomponentsofcognitiveprocesses AT illahjoshi plasticityind1likereceptorexpressionisassociatedwithdifferentcomponentsofcognitiveprocesses AT omarchehadi plasticityind1likereceptorexpressionisassociatedwithdifferentcomponentsofcognitiveprocesses AT michaelhollmann plasticityind1likereceptorexpressionisassociatedwithdifferentcomponentsofcognitiveprocesses AT onurgunturkun plasticityind1likereceptorexpressionisassociatedwithdifferentcomponentsofcognitiveprocesses
_version_	1718423585219936256

Plasticity in D1-like receptor expression is associated with different components of cognitive processes.

Ejemplares similares