IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

The alternative mechanisms of innate immunity in tumorigenesis of colorectal cancers are unclear. Here, the authors report a non-canonical function of IRF3, a mediator of innate immune signalling, in the suppression of colorectal tumorigenesis and this is via the inhibition of Wnt/β-catenin pathway....

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Autores principales:	Miao Tian, Xiumei Wang, Jihong Sun, Wenlong Lin, Lumin Chen, Shengduo Liu, Ximei Wu, Liyun Shi, Pinglong Xu, Xiujun Cai, Xiaojian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27fd64e8f5954df280d638580267b400
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spelling	oai:doaj.org-article:27fd64e8f5954df280d638580267b4002021-12-02T15:34:34ZIRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin10.1038/s41467-020-19627-72041-1723https://doaj.org/article/27fd64e8f5954df280d638580267b4002020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19627-7https://doaj.org/toc/2041-1723The alternative mechanisms of innate immunity in tumorigenesis of colorectal cancers are unclear. Here, the authors report a non-canonical function of IRF3, a mediator of innate immune signalling, in the suppression of colorectal tumorigenesis and this is via the inhibition of Wnt/β-catenin pathway.Miao TianXiumei WangJihong SunWenlong LinLumin ChenShengduo LiuXimei WuLiyun ShiPinglong XuXiujun CaiXiaojian WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miao Tian Xiumei Wang Jihong Sun Wenlong Lin Lumin Chen Shengduo Liu Ximei Wu Liyun Shi Pinglong Xu Xiujun Cai Xiaojian Wang IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
description	The alternative mechanisms of innate immunity in tumorigenesis of colorectal cancers are unclear. Here, the authors report a non-canonical function of IRF3, a mediator of innate immune signalling, in the suppression of colorectal tumorigenesis and this is via the inhibition of Wnt/β-catenin pathway.
format	article
author	Miao Tian Xiumei Wang Jihong Sun Wenlong Lin Lumin Chen Shengduo Liu Ximei Wu Liyun Shi Pinglong Xu Xiujun Cai Xiaojian Wang
author_facet	Miao Tian Xiumei Wang Jihong Sun Wenlong Lin Lumin Chen Shengduo Liu Ximei Wu Liyun Shi Pinglong Xu Xiujun Cai Xiaojian Wang
author_sort	Miao Tian
title	IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
title_short	IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
title_full	IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
title_fullStr	IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
title_full_unstemmed	IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
title_sort	irf3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/27fd64e8f5954df280d638580267b400
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IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

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