A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.

Polarization, a primary step in the response of an individual eukaryotic cell to a spatial stimulus, has attracted numerous theoretical treatments complementing experimental studies in a variety of cell types. While the phenomenon itself is universal, details differ across cell types, and across cla...

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Autores principales:	Alexandra Jilkine, Leah Edelstein-Keshet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/27fec57713944a72955bd60c7ee529da
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id	oai:doaj.org-article:27fec57713944a72955bd60c7ee529da
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spelling	oai:doaj.org-article:27fec57713944a72955bd60c7ee529da2021-11-18T05:50:34ZA comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.1553-734X1553-735810.1371/journal.pcbi.1001121https://doaj.org/article/27fec57713944a72955bd60c7ee529da2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21552548/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Polarization, a primary step in the response of an individual eukaryotic cell to a spatial stimulus, has attracted numerous theoretical treatments complementing experimental studies in a variety of cell types. While the phenomenon itself is universal, details differ across cell types, and across classes of models that have been proposed. Most models address how symmetry breaking leads to polarization, some in abstract settings, others based on specific biochemistry. Here, we compare polarization in response to a stimulus (e.g., a chemoattractant) in cells typically used in experiments (yeast, amoebae, leukocytes, keratocytes, fibroblasts, and neurons), and, in parallel, responses of several prototypical models to typical stimulation protocols. We find that the diversity of cell behaviors is reflected by a diversity of models, and that some, but not all models, can account for amplification of stimulus, maintenance of polarity, adaptation, sensitivity to new signals, and robustness.Alexandra JilkineLeah Edelstein-KeshetPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 4, p e1001121 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alexandra Jilkine Leah Edelstein-Keshet A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
description	Polarization, a primary step in the response of an individual eukaryotic cell to a spatial stimulus, has attracted numerous theoretical treatments complementing experimental studies in a variety of cell types. While the phenomenon itself is universal, details differ across cell types, and across classes of models that have been proposed. Most models address how symmetry breaking leads to polarization, some in abstract settings, others based on specific biochemistry. Here, we compare polarization in response to a stimulus (e.g., a chemoattractant) in cells typically used in experiments (yeast, amoebae, leukocytes, keratocytes, fibroblasts, and neurons), and, in parallel, responses of several prototypical models to typical stimulation protocols. We find that the diversity of cell behaviors is reflected by a diversity of models, and that some, but not all models, can account for amplification of stimulus, maintenance of polarity, adaptation, sensitivity to new signals, and robustness.
format	article
author	Alexandra Jilkine Leah Edelstein-Keshet
author_facet	Alexandra Jilkine Leah Edelstein-Keshet
author_sort	Alexandra Jilkine
title	A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
title_short	A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
title_full	A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
title_fullStr	A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
title_full_unstemmed	A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
title_sort	comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/27fec57713944a72955bd60c7ee529da
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A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.

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