Environmental arginine controls multinuclear giant cell metabolism and formation

Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine dep...

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Autores principales:	Julia S. Brunner, Loan Vulliard, Melanie Hofmann, Markus Kieler, Alexander Lercher, Andrea Vogel, Marion Russier, Johanna B. Brüggenthies, Martina Kerndl, Victoria Saferding, Birgit Niederreiter, Alexandra Junza, Annika Frauenstein, Carina Scholtysek, Yohei Mikami, Kristaps Klavins, Gerhard Krönke, Andreas Bergthaler, John J. O’Shea, Thomas Weichhart, Felix Meissner, Josef S. Smolen, Paul Cheng, Oscar Yanes, Jörg Menche, Peter J. Murray, Omar Sharif, Stephan Blüml, Gernot Schabbauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28055bd4c7454a9b869483a12530bfc2
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spelling	oai:doaj.org-article:28055bd4c7454a9b869483a12530bfc22021-12-02T15:39:25ZEnvironmental arginine controls multinuclear giant cell metabolism and formation10.1038/s41467-020-14285-12041-1723https://doaj.org/article/28055bd4c7454a9b869483a12530bfc22020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14285-1https://doaj.org/toc/2041-1723Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.Julia S. BrunnerLoan VulliardMelanie HofmannMarkus KielerAlexander LercherAndrea VogelMarion RussierJohanna B. BrüggenthiesMartina KerndlVictoria SaferdingBirgit NiederreiterAlexandra JunzaAnnika FrauensteinCarina ScholtysekYohei MikamiKristaps KlavinsGerhard KrönkeAndreas BergthalerJohn J. O’SheaThomas WeichhartFelix MeissnerJosef S. SmolenPaul ChengOscar YanesJörg MenchePeter J. MurrayOmar SharifStephan BlümlGernot SchabbauerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia S. Brunner Loan Vulliard Melanie Hofmann Markus Kieler Alexander Lercher Andrea Vogel Marion Russier Johanna B. Brüggenthies Martina Kerndl Victoria Saferding Birgit Niederreiter Alexandra Junza Annika Frauenstein Carina Scholtysek Yohei Mikami Kristaps Klavins Gerhard Krönke Andreas Bergthaler John J. O’Shea Thomas Weichhart Felix Meissner Josef S. Smolen Paul Cheng Oscar Yanes Jörg Menche Peter J. Murray Omar Sharif Stephan Blüml Gernot Schabbauer Environmental arginine controls multinuclear giant cell metabolism and formation
description	Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.
format	article
author	Julia S. Brunner Loan Vulliard Melanie Hofmann Markus Kieler Alexander Lercher Andrea Vogel Marion Russier Johanna B. Brüggenthies Martina Kerndl Victoria Saferding Birgit Niederreiter Alexandra Junza Annika Frauenstein Carina Scholtysek Yohei Mikami Kristaps Klavins Gerhard Krönke Andreas Bergthaler John J. O’Shea Thomas Weichhart Felix Meissner Josef S. Smolen Paul Cheng Oscar Yanes Jörg Menche Peter J. Murray Omar Sharif Stephan Blüml Gernot Schabbauer
author_facet	Julia S. Brunner Loan Vulliard Melanie Hofmann Markus Kieler Alexander Lercher Andrea Vogel Marion Russier Johanna B. Brüggenthies Martina Kerndl Victoria Saferding Birgit Niederreiter Alexandra Junza Annika Frauenstein Carina Scholtysek Yohei Mikami Kristaps Klavins Gerhard Krönke Andreas Bergthaler John J. O’Shea Thomas Weichhart Felix Meissner Josef S. Smolen Paul Cheng Oscar Yanes Jörg Menche Peter J. Murray Omar Sharif Stephan Blüml Gernot Schabbauer
author_sort	Julia S. Brunner
title	Environmental arginine controls multinuclear giant cell metabolism and formation
title_short	Environmental arginine controls multinuclear giant cell metabolism and formation
title_full	Environmental arginine controls multinuclear giant cell metabolism and formation
title_fullStr	Environmental arginine controls multinuclear giant cell metabolism and formation
title_full_unstemmed	Environmental arginine controls multinuclear giant cell metabolism and formation
title_sort	environmental arginine controls multinuclear giant cell metabolism and formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/28055bd4c7454a9b869483a12530bfc2
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Environmental arginine controls multinuclear giant cell metabolism and formation

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