Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease

Abstract Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant stat...

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Autores principales:	Aleksandra Klisic, Nebojsa Kavaric, Ana Ninic, Jelena Kotur-Stevuljevic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2806896ecb58435fa845e7a06a63e76c
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spelling	oai:doaj.org-article:2806896ecb58435fa845e7a06a63e76c2021-12-02T18:02:23ZOxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease10.1038/s41598-021-97686-62045-2322https://doaj.org/article/2806896ecb58435fa845e7a06a63e76c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97686-6https://doaj.org/toc/2045-2322Abstract Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS) and oxidative-stress index (OSI)] and cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed to investigate this potential relationship. A total of 122 subjects with NAFLD were compared with 56 participants without NAFLD. The diagnosis of NAFLD was confirmed by abdominal ultrasound. Anthropometric and biochemical parameters were measured. OSI, Castelli’s Risk Index I (CRI-I) and Castelli’s Risk Index II (CRI-II) were calculated. Univariate and multivariate binary logistic regression analysis were used to test the predictions of oxidative stress and cardiometabolic markers, respectively for NAFLD. Principal component analysis (PCA) was applied to explore its mutual effect on NAFLD status. Significant positive associations of CRI-I, CRI-II, high sensitivity C-reactive protein (hsCRP) and AOPP with NAFLD were found. PCA analysis extracted 3 significant factors: Oxidative stress-cardiometabolic related factor (i.e., triglycerides, AOPP, HDL-c and HbA1c)-explained 36% of variance; Pro-oxidants related factor (i.e., TOS and PAB)-explained 17% of variance; and Antioxidants related factor (i.e., TAS)-explained 15% of variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant predictive ability of Oxidative stress-cardiometabolic related factor (p < 0.001) and Pro-oxidants related factor (p < 0.05) for NAFLD status. In addition to oxidative stress (i.e., determined by higher AOPP levels), dyslipidemia (i.e., determined by higher lipid indexes: CRI-I and CRI-II) and inflammation (determined by higher hsCRP) are independently related to NAFLD status. The mutual involvement of pro-oxidants (i.e., TOS and PAB), or the joint involvement of pro-oxidants (i.e., AOPP) and cardiometabolic parameters (i.e., HbA1c, triglycerides and HDL-c) can differentiate subjects with NAFLD from those individuals without this metabolic disorder. New studies are needed to validate our results in order to find the best therapeutic approach for NAFLD.Aleksandra KlisicNebojsa KavaricAna NinicJelena Kotur-StevuljevicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aleksandra Klisic Nebojsa Kavaric Ana Ninic Jelena Kotur-Stevuljevic Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
description	Abstract Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS) and oxidative-stress index (OSI)] and cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed to investigate this potential relationship. A total of 122 subjects with NAFLD were compared with 56 participants without NAFLD. The diagnosis of NAFLD was confirmed by abdominal ultrasound. Anthropometric and biochemical parameters were measured. OSI, Castelli’s Risk Index I (CRI-I) and Castelli’s Risk Index II (CRI-II) were calculated. Univariate and multivariate binary logistic regression analysis were used to test the predictions of oxidative stress and cardiometabolic markers, respectively for NAFLD. Principal component analysis (PCA) was applied to explore its mutual effect on NAFLD status. Significant positive associations of CRI-I, CRI-II, high sensitivity C-reactive protein (hsCRP) and AOPP with NAFLD were found. PCA analysis extracted 3 significant factors: Oxidative stress-cardiometabolic related factor (i.e., triglycerides, AOPP, HDL-c and HbA1c)-explained 36% of variance; Pro-oxidants related factor (i.e., TOS and PAB)-explained 17% of variance; and Antioxidants related factor (i.e., TAS)-explained 15% of variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant predictive ability of Oxidative stress-cardiometabolic related factor (p < 0.001) and Pro-oxidants related factor (p < 0.05) for NAFLD status. In addition to oxidative stress (i.e., determined by higher AOPP levels), dyslipidemia (i.e., determined by higher lipid indexes: CRI-I and CRI-II) and inflammation (determined by higher hsCRP) are independently related to NAFLD status. The mutual involvement of pro-oxidants (i.e., TOS and PAB), or the joint involvement of pro-oxidants (i.e., AOPP) and cardiometabolic parameters (i.e., HbA1c, triglycerides and HDL-c) can differentiate subjects with NAFLD from those individuals without this metabolic disorder. New studies are needed to validate our results in order to find the best therapeutic approach for NAFLD.
format	article
author	Aleksandra Klisic Nebojsa Kavaric Ana Ninic Jelena Kotur-Stevuljevic
author_facet	Aleksandra Klisic Nebojsa Kavaric Ana Ninic Jelena Kotur-Stevuljevic
author_sort	Aleksandra Klisic
title	Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
title_short	Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
title_full	Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
title_fullStr	Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
title_full_unstemmed	Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
title_sort	oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2806896ecb58435fa845e7a06a63e76c
work_keys_str_mv	AT aleksandraklisic oxidativestressandcardiometabolicbiomarkersinpatientswithnonalcoholicfattyliverdisease AT nebojsakavaric oxidativestressandcardiometabolicbiomarkersinpatientswithnonalcoholicfattyliverdisease AT ananinic oxidativestressandcardiometabolicbiomarkersinpatientswithnonalcoholicfattyliverdisease AT jelenakoturstevuljevic oxidativestressandcardiometabolicbiomarkersinpatientswithnonalcoholicfattyliverdisease
_version_	1718378916761042944

Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease

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