Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Caveolae are spherical nanodomains of the plasma membrane generated by assembly of caveolin and cavin proteins. Here, the authors show that fuzzy electrostatic interactions between caveolin-1 and Cavin1 proteins, combined with membrane lipid interactions, are required to generate membrane curvature...

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Autores principales:	Vikas A. Tillu, James Rae, Ya Gao, Nicholas Ariotti, Matthias Floetenmeyer, Oleksiy Kovtun, Kerrie-Ann McMahon, Natasha Chaudhary, Robert G. Parton, Brett M. Collins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2807bb40181f4244bd067fd1cb562ab3
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spelling	oai:doaj.org-article:2807bb40181f4244bd067fd1cb562ab32021-12-02T13:30:15ZCavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation10.1038/s41467-021-21035-42041-1723https://doaj.org/article/2807bb40181f4244bd067fd1cb562ab32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21035-4https://doaj.org/toc/2041-1723Caveolae are spherical nanodomains of the plasma membrane generated by assembly of caveolin and cavin proteins. Here, the authors show that fuzzy electrostatic interactions between caveolin-1 and Cavin1 proteins, combined with membrane lipid interactions, are required to generate membrane curvature and a metastable caveola coat.Vikas A. TilluJames RaeYa GaoNicholas AriottiMatthias FloetenmeyerOleksiy KovtunKerrie-Ann McMahonNatasha ChaudharyRobert G. PartonBrett M. CollinsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vikas A. Tillu James Rae Ya Gao Nicholas Ariotti Matthias Floetenmeyer Oleksiy Kovtun Kerrie-Ann McMahon Natasha Chaudhary Robert G. Parton Brett M. Collins Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
description	Caveolae are spherical nanodomains of the plasma membrane generated by assembly of caveolin and cavin proteins. Here, the authors show that fuzzy electrostatic interactions between caveolin-1 and Cavin1 proteins, combined with membrane lipid interactions, are required to generate membrane curvature and a metastable caveola coat.
format	article
author	Vikas A. Tillu James Rae Ya Gao Nicholas Ariotti Matthias Floetenmeyer Oleksiy Kovtun Kerrie-Ann McMahon Natasha Chaudhary Robert G. Parton Brett M. Collins
author_facet	Vikas A. Tillu James Rae Ya Gao Nicholas Ariotti Matthias Floetenmeyer Oleksiy Kovtun Kerrie-Ann McMahon Natasha Chaudhary Robert G. Parton Brett M. Collins
author_sort	Vikas A. Tillu
title	Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
title_short	Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
title_full	Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
title_fullStr	Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
title_full_unstemmed	Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
title_sort	cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2807bb40181f4244bd067fd1cb562ab3
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Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

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