Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants

Li Zhang, El-Mustapha Haddouti, Kristian Welle, Christof Burger, Koroush Kabir,* Frank A Schildberg* Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany*These authors contributed equally to this workCorrespondence: Koroush Kabir; Frank A Schil...

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Autores principales:	Zhang L, Haddouti EM, Welle K, Burger C, Kabir K, Schildberg FA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanoparticles joint arthroplasty osteoblasts osteoclasts macrophages mesenchymal stem cells Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2807fdf19c514be1b5dc5d2b9f8b42a4
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spelling	oai:doaj.org-article:2807fdf19c514be1b5dc5d2b9f8b42a42021-12-02T12:34:28ZLocal Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants1178-2013https://doaj.org/article/2807fdf19c514be1b5dc5d2b9f8b42a42020-09-01T00:00:00Zhttps://www.dovepress.com/local-cellular-responses-to-metallic-and-ceramic-nanoparticles-from-or-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Li Zhang, El-Mustapha Haddouti, Kristian Welle, Christof Burger, Koroush Kabir,* Frank A Schildberg* Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany*These authors contributed equally to this workCorrespondence: Koroush Kabir; Frank A Schildberg Email koroush.kabir@ukbonn.de; frank.schildberg@ukbonn.deAbstract: Over the last decades, joint arthroplasty has become a successful treatment for joint disease. Nowadays, with a growing demand and increasingly younger and active patients accepting these approaches, orthopedic surgeons are seeking implants with improved mechanical behavior and longer life span. However, aseptic loosening as a result of wear debris from implants is considered to be the main cause of long-term implant failure. Previous studies have neatly illustrated the role of micrometric wear particles in the pathological mechanisms underlying aseptic loosening. Recent osteoimmunologic insights into aseptic loosening highlight the important and heretofore underrepresented contribution of nanometric orthopedic wear particles. The present review updates the characteristics of metallic and ceramic nanoparticles generated after prosthesis implantation and summarizes the current understanding of their hazardous effects on peri-prosthetic cells.Keywords: nanoparticles, joint arthroplasty, osteoblasts, osteoclasts, macrophages, mesenchymal stem cellsZhang LHaddouti EMWelle KBurger CKabir KSchildberg FADove Medical Pressarticlenanoparticlesjoint arthroplastyosteoblastsosteoclastsmacrophagesmesenchymal stem cellsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6705-6720 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles joint arthroplasty osteoblasts osteoclasts macrophages mesenchymal stem cells Medicine (General) R5-920
spellingShingle	nanoparticles joint arthroplasty osteoblasts osteoclasts macrophages mesenchymal stem cells Medicine (General) R5-920 Zhang L Haddouti EM Welle K Burger C Kabir K Schildberg FA Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
description	Li Zhang, El-Mustapha Haddouti, Kristian Welle, Christof Burger, Koroush Kabir,* Frank A Schildberg* Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany*These authors contributed equally to this workCorrespondence: Koroush Kabir; Frank A Schildberg Email koroush.kabir@ukbonn.de; frank.schildberg@ukbonn.deAbstract: Over the last decades, joint arthroplasty has become a successful treatment for joint disease. Nowadays, with a growing demand and increasingly younger and active patients accepting these approaches, orthopedic surgeons are seeking implants with improved mechanical behavior and longer life span. However, aseptic loosening as a result of wear debris from implants is considered to be the main cause of long-term implant failure. Previous studies have neatly illustrated the role of micrometric wear particles in the pathological mechanisms underlying aseptic loosening. Recent osteoimmunologic insights into aseptic loosening highlight the important and heretofore underrepresented contribution of nanometric orthopedic wear particles. The present review updates the characteristics of metallic and ceramic nanoparticles generated after prosthesis implantation and summarizes the current understanding of their hazardous effects on peri-prosthetic cells.Keywords: nanoparticles, joint arthroplasty, osteoblasts, osteoclasts, macrophages, mesenchymal stem cells
format	article
author	Zhang L Haddouti EM Welle K Burger C Kabir K Schildberg FA
author_facet	Zhang L Haddouti EM Welle K Burger C Kabir K Schildberg FA
author_sort	Zhang L
title	Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
title_short	Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
title_full	Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
title_fullStr	Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
title_full_unstemmed	Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
title_sort	local cellular responses to metallic and ceramic nanoparticles from orthopedic joint arthroplasty implants
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2807fdf19c514be1b5dc5d2b9f8b42a4
work_keys_str_mv	AT zhangl localcellularresponsestometallicandceramicnanoparticlesfromorthopedicjointarthroplastyimplants AT haddoutiem localcellularresponsestometallicandceramicnanoparticlesfromorthopedicjointarthroplastyimplants AT wellek localcellularresponsestometallicandceramicnanoparticlesfromorthopedicjointarthroplastyimplants AT burgerc localcellularresponsestometallicandceramicnanoparticlesfromorthopedicjointarthroplastyimplants AT kabirk localcellularresponsestometallicandceramicnanoparticlesfromorthopedicjointarthroplastyimplants AT schildbergfa localcellularresponsestometallicandceramicnanoparticlesfromorthopedicjointarthroplastyimplants
_version_	1718393788606447616

Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants

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