Titan cell formation is unique to Cryptococcus species complex

Members of the Cryptococcus species complex stand out by unique virulence factors that allowed evolutionary transition to pathogenesis. Among the factors contributing to cryptococcosis is a morphological transformation into giant (Titan) cells. It remains unclear whether species outside of the C. ne...

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Autores principales:	Mariusz Dyląg, Rodney J. Colon-Reyes, Lukasz Kozubowski
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	fungi virulence factors pathogenicity cryptococcosis morphological transition Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2809fa7c39b64128ab5ed2c387168d0c
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spelling	oai:doaj.org-article:2809fa7c39b64128ab5ed2c387168d0c2021-11-17T14:21:58ZTitan cell formation is unique to Cryptococcus species complex2150-55942150-560810.1080/21505594.2020.1772657https://doaj.org/article/2809fa7c39b64128ab5ed2c387168d0c2020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1772657https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Members of the Cryptococcus species complex stand out by unique virulence factors that allowed evolutionary transition to pathogenesis. Among the factors contributing to cryptococcosis is a morphological transformation into giant (Titan) cells. It remains unclear whether species outside of the C. neoformans/C. gattii species complex are capable of titanization. We utilized two recently developed protocols that allow obtaining Titan cells in vitro to test if titanization occurs in non-C. neoformans/C. gattii species. We find that none of the tested strains, representing 10 species of basidiomycetous yeasts and the ascomycetous yeast Saccharomyces cerevisiae, undergo significant titanization under conditions that promote robust Titan cell formation in C. neoformans/C. gattii species complex. C. terreus formed occasional enlarged cells through a mechanism potentially similar to that of titanization. Our findings suggest that titanization is a rare phenomenon among basidiomycetous yeasts that occurs mostly in members of the C. neoformans/C. gattii species complex.Mariusz DylągRodney J. Colon-ReyesLukasz KozubowskiTaylor & Francis Grouparticlefungivirulence factorspathogenicitycryptococcosismorphological transitionInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 719-729 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	fungi virulence factors pathogenicity cryptococcosis morphological transition Infectious and parasitic diseases RC109-216
spellingShingle	fungi virulence factors pathogenicity cryptococcosis morphological transition Infectious and parasitic diseases RC109-216 Mariusz Dyląg Rodney J. Colon-Reyes Lukasz Kozubowski Titan cell formation is unique to Cryptococcus species complex
description	Members of the Cryptococcus species complex stand out by unique virulence factors that allowed evolutionary transition to pathogenesis. Among the factors contributing to cryptococcosis is a morphological transformation into giant (Titan) cells. It remains unclear whether species outside of the C. neoformans/C. gattii species complex are capable of titanization. We utilized two recently developed protocols that allow obtaining Titan cells in vitro to test if titanization occurs in non-C. neoformans/C. gattii species. We find that none of the tested strains, representing 10 species of basidiomycetous yeasts and the ascomycetous yeast Saccharomyces cerevisiae, undergo significant titanization under conditions that promote robust Titan cell formation in C. neoformans/C. gattii species complex. C. terreus formed occasional enlarged cells through a mechanism potentially similar to that of titanization. Our findings suggest that titanization is a rare phenomenon among basidiomycetous yeasts that occurs mostly in members of the C. neoformans/C. gattii species complex.
format	article
author	Mariusz Dyląg Rodney J. Colon-Reyes Lukasz Kozubowski
author_facet	Mariusz Dyląg Rodney J. Colon-Reyes Lukasz Kozubowski
author_sort	Mariusz Dyląg
title	Titan cell formation is unique to Cryptococcus species complex
title_short	Titan cell formation is unique to Cryptococcus species complex
title_full	Titan cell formation is unique to Cryptococcus species complex
title_fullStr	Titan cell formation is unique to Cryptococcus species complex
title_full_unstemmed	Titan cell formation is unique to Cryptococcus species complex
title_sort	titan cell formation is unique to cryptococcus species complex
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/2809fa7c39b64128ab5ed2c387168d0c
work_keys_str_mv	AT mariuszdylag titancellformationisuniquetocryptococcusspeciescomplex AT rodneyjcolonreyes titancellformationisuniquetocryptococcusspeciescomplex AT lukaszkozubowski titancellformationisuniquetocryptococcusspeciescomplex
_version_	1718425470820679680

Titan cell formation is unique to Cryptococcus species complex

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