Neurogenesis response of middle-aged hippocampus to acute seizure activity.

Acute Seizure (AS) activity in young adult age conspicuously modifies hippocampal neurogenesis. This is epitomized by both increased addition of new neurons to the granule cell layer (GCL) by neural stem/progenitor cells (NSCs) in the dentate subgranular zone (SGZ), and greatly enhanced numbers of n...

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Autores principales:	Ashok K Shetty, Bharathi Hattiangady, Muddanna S Rao, Bing Shuai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/280bd6c18b9b44cea275dd4dac9fbabc
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spelling	oai:doaj.org-article:280bd6c18b9b44cea275dd4dac9fbabc2021-11-18T07:08:24ZNeurogenesis response of middle-aged hippocampus to acute seizure activity.1932-620310.1371/journal.pone.0043286https://doaj.org/article/280bd6c18b9b44cea275dd4dac9fbabc2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912847/?tool=EBIhttps://doaj.org/toc/1932-6203Acute Seizure (AS) activity in young adult age conspicuously modifies hippocampal neurogenesis. This is epitomized by both increased addition of new neurons to the granule cell layer (GCL) by neural stem/progenitor cells (NSCs) in the dentate subgranular zone (SGZ), and greatly enhanced numbers of newly born neurons located abnormally in the dentate hilus (DH). Interestingly, AS activity in old age does not induce such changes in hippocampal neurogenesis. However, the effect of AS activity on neurogenesis in the middle-aged hippocampus is yet to be elucidated. We examined hippocampal neurogenesis in middle-aged F344 rats after a continuous AS activity for >4 hrs, induced through graded intraperitoneal injections of the kainic acid. We labeled newly born cells via daily intraperitoneal injections of the 5'-bromodeoxyuridine (BrdU) for 12 days, commencing from the day of induction of AS activity. AS activity enhanced the addition of newly born BrdU+ cells by 5.6 fold and newly born neurons (expressing both BrdU and doublecortin [DCX]) by 2.2 fold to the SGZ-GCL. Measurement of the total number of DCX+ newly born neurons also revealed a similar trend. Furthermore, AS activity increased DCX+ newly born neurons located ectopically in the DH (2.7 fold increase and 17% of total newly born neurons). This rate of ectopic migration is however considerably less than what was observed earlier for the young adult hippocampus after similar AS activity. Thus, the plasticity of hippocampal neurogenesis to AS activity in middle age is closer to its response observed in the young adult age. However, the extent of abnormal migration of newly born neurons into the DH is less than that of the young adult hippocampus after similar AS activity. These results also point out a highly divergent response of neurogenesis to AS activity between middle age and old age.Ashok K ShettyBharathi HattiangadyMuddanna S RaoBing ShuaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43286 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashok K Shetty Bharathi Hattiangady Muddanna S Rao Bing Shuai Neurogenesis response of middle-aged hippocampus to acute seizure activity.
description	Acute Seizure (AS) activity in young adult age conspicuously modifies hippocampal neurogenesis. This is epitomized by both increased addition of new neurons to the granule cell layer (GCL) by neural stem/progenitor cells (NSCs) in the dentate subgranular zone (SGZ), and greatly enhanced numbers of newly born neurons located abnormally in the dentate hilus (DH). Interestingly, AS activity in old age does not induce such changes in hippocampal neurogenesis. However, the effect of AS activity on neurogenesis in the middle-aged hippocampus is yet to be elucidated. We examined hippocampal neurogenesis in middle-aged F344 rats after a continuous AS activity for >4 hrs, induced through graded intraperitoneal injections of the kainic acid. We labeled newly born cells via daily intraperitoneal injections of the 5'-bromodeoxyuridine (BrdU) for 12 days, commencing from the day of induction of AS activity. AS activity enhanced the addition of newly born BrdU+ cells by 5.6 fold and newly born neurons (expressing both BrdU and doublecortin [DCX]) by 2.2 fold to the SGZ-GCL. Measurement of the total number of DCX+ newly born neurons also revealed a similar trend. Furthermore, AS activity increased DCX+ newly born neurons located ectopically in the DH (2.7 fold increase and 17% of total newly born neurons). This rate of ectopic migration is however considerably less than what was observed earlier for the young adult hippocampus after similar AS activity. Thus, the plasticity of hippocampal neurogenesis to AS activity in middle age is closer to its response observed in the young adult age. However, the extent of abnormal migration of newly born neurons into the DH is less than that of the young adult hippocampus after similar AS activity. These results also point out a highly divergent response of neurogenesis to AS activity between middle age and old age.
format	article
author	Ashok K Shetty Bharathi Hattiangady Muddanna S Rao Bing Shuai
author_facet	Ashok K Shetty Bharathi Hattiangady Muddanna S Rao Bing Shuai
author_sort	Ashok K Shetty
title	Neurogenesis response of middle-aged hippocampus to acute seizure activity.
title_short	Neurogenesis response of middle-aged hippocampus to acute seizure activity.
title_full	Neurogenesis response of middle-aged hippocampus to acute seizure activity.
title_fullStr	Neurogenesis response of middle-aged hippocampus to acute seizure activity.
title_full_unstemmed	Neurogenesis response of middle-aged hippocampus to acute seizure activity.
title_sort	neurogenesis response of middle-aged hippocampus to acute seizure activity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/280bd6c18b9b44cea275dd4dac9fbabc
work_keys_str_mv	AT ashokkshetty neurogenesisresponseofmiddleagedhippocampustoacuteseizureactivity AT bharathihattiangady neurogenesisresponseofmiddleagedhippocampustoacuteseizureactivity AT muddannasrao neurogenesisresponseofmiddleagedhippocampustoacuteseizureactivity AT bingshuai neurogenesisresponseofmiddleagedhippocampustoacuteseizureactivity
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Neurogenesis response of middle-aged hippocampus to acute seizure activity.

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