Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.

<h4>Background</h4>Ulcerative colitis (UC) is a chronic inflammatory disease with an increasing incidence in the world. Qingre-Chushi therapies (QC) can alleviate clinical symptoms. Therefore, a network meta-analysis was conducted to systematically evaluate the efficacy and safety of QC...

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Autores principales:	Ling Zhang, Yun-Bo Wu, Yun-Kai Dai, Qi Liu, Yu-Jie Ren, Shi-Jie Xu, Huai-Geng Pan, Wei-Jing Chen, Ru-Liu Li, Ling Hu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/280d4c16e9c94ec3b340ded1bff6ff7e
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spelling	oai:doaj.org-article:280d4c16e9c94ec3b340ded1bff6ff7e2021-12-02T20:14:29ZEfficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.1932-620310.1371/journal.pone.0257599https://doaj.org/article/280d4c16e9c94ec3b340ded1bff6ff7e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257599https://doaj.org/toc/1932-6203<h4>Background</h4>Ulcerative colitis (UC) is a chronic inflammatory disease with an increasing incidence in the world. Qingre-Chushi therapies (QC) can alleviate clinical symptoms. Therefore, a network meta-analysis was conducted to systematically evaluate the efficacy and safety of QC in the treatment of active UC patients.<h4>Methods</h4>7 databases were screened and relevant randomized controlled trials were selected. The tools of Cochrane Handbook and the GRADE system were conducted to assess the quality of outcomes. Pooled risk ratio or standard mean difference was calculated with 95% credible interval for outcomes measurement using the random-effects model. The surface under the cumulative ranking curve (SUCRA) was performed to rank the treatments. The larger SUCRA scores, the more effective interventions.<h4>Results</h4>A total of 3560 articles were identified and 21 studies including 1829 participants were included for further analysis. Totally, 9 therapies regimens were compared: oral mesalazine, mesalazine enema, mesalazine suppository, oral mesalazine + mesalazine enema, oral QC, oral QC + oral mesalazine, QC enema, oral QC + QC enema, and oral mesalazine + QC enema. Based on the SUCRA plot, oral QC + oral mesalazine was the best treatment in inducing clinical response; oral QC + QC enema had the best efficacy in the improvement of Mayo scores and alleviating abdominal pain; oral mesalazine + mesalazine enema was the optimal therapy in the endoscopic improvement and reducing diarrhea; QC enema + oral mesalazine was the best option in preventing bloody stool.<h4>Conclusion</h4>This study confirmed the efficacy and safety of QC in treating active UC and suggested that the combination of oral medications with topical can achieve more benefits.Ling ZhangYun-Bo WuYun-Kai DaiQi LiuYu-Jie RenShi-Jie XuHuai-Geng PanWei-Jing ChenRu-Liu LiLing HuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257599 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ling Zhang Yun-Bo Wu Yun-Kai Dai Qi Liu Yu-Jie Ren Shi-Jie Xu Huai-Geng Pan Wei-Jing Chen Ru-Liu Li Ling Hu Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.
description	<h4>Background</h4>Ulcerative colitis (UC) is a chronic inflammatory disease with an increasing incidence in the world. Qingre-Chushi therapies (QC) can alleviate clinical symptoms. Therefore, a network meta-analysis was conducted to systematically evaluate the efficacy and safety of QC in the treatment of active UC patients.<h4>Methods</h4>7 databases were screened and relevant randomized controlled trials were selected. The tools of Cochrane Handbook and the GRADE system were conducted to assess the quality of outcomes. Pooled risk ratio or standard mean difference was calculated with 95% credible interval for outcomes measurement using the random-effects model. The surface under the cumulative ranking curve (SUCRA) was performed to rank the treatments. The larger SUCRA scores, the more effective interventions.<h4>Results</h4>A total of 3560 articles were identified and 21 studies including 1829 participants were included for further analysis. Totally, 9 therapies regimens were compared: oral mesalazine, mesalazine enema, mesalazine suppository, oral mesalazine + mesalazine enema, oral QC, oral QC + oral mesalazine, QC enema, oral QC + QC enema, and oral mesalazine + QC enema. Based on the SUCRA plot, oral QC + oral mesalazine was the best treatment in inducing clinical response; oral QC + QC enema had the best efficacy in the improvement of Mayo scores and alleviating abdominal pain; oral mesalazine + mesalazine enema was the optimal therapy in the endoscopic improvement and reducing diarrhea; QC enema + oral mesalazine was the best option in preventing bloody stool.<h4>Conclusion</h4>This study confirmed the efficacy and safety of QC in treating active UC and suggested that the combination of oral medications with topical can achieve more benefits.
format	article
author	Ling Zhang Yun-Bo Wu Yun-Kai Dai Qi Liu Yu-Jie Ren Shi-Jie Xu Huai-Geng Pan Wei-Jing Chen Ru-Liu Li Ling Hu
author_facet	Ling Zhang Yun-Bo Wu Yun-Kai Dai Qi Liu Yu-Jie Ren Shi-Jie Xu Huai-Geng Pan Wei-Jing Chen Ru-Liu Li Ling Hu
author_sort	Ling Zhang
title	Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.
title_short	Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.
title_full	Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.
title_fullStr	Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.
title_full_unstemmed	Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.
title_sort	efficacy and safety of qingre-chushi therapies in active ulcerative colitis: a network meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/280d4c16e9c94ec3b340ded1bff6ff7e
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Efficacy and safety of Qingre-Chushi therapies in active ulcerative colitis: A network meta-analysis.

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