Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

Abstract Background In areas where Lyme disease is endemic, bites from ticks are common, but no vaccine is currently available against Lyme disease for humans. Therefore, the feasibility of using antibiotic prophylaxis to prevent Lyme disease after a tick bite is worth further exploration. Previous...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guozhong Zhou, Xin Xu, Yu Zhang, Peng Yue, Shiqi Luo, Yuxin Fan, Jingjing Chen, Meixiao Liu, Yan Dong, Bingxue Li, Jing Kong, Shiyuan Wen, Aihua Liu, Fukai Bao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Borrelia burgdorferi Borreliosis Ixodes Lyme disease Tick bite Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/280ec6ec224e4649bedfbd65b99d17bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:280ec6ec224e4649bedfbd65b99d17bc
record_format	dspace
spelling	oai:doaj.org-article:280ec6ec224e4649bedfbd65b99d17bc2021-11-14T12:44:29ZAntibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis10.1186/s12879-021-06837-71471-2334https://doaj.org/article/280ec6ec224e4649bedfbd65b99d17bc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06837-7https://doaj.org/toc/1471-2334Abstract Background In areas where Lyme disease is endemic, bites from ticks are common, but no vaccine is currently available against Lyme disease for humans. Therefore, the feasibility of using antibiotic prophylaxis to prevent Lyme disease after a tick bite is worth further exploration. Previous meta-analyses lack sufficient power to demonstrate the efficacy of about antibiotic prophylaxis for the prevention of Lyme disease following a tick bite. In this study, we explored more precise evidence and attempted to identify and update optimum treatment strategies. Methods We searched PubMed, Embase, and the Cochrane Library for studies until March 23, 2021. We included studies if the enrolled patients were randomly allocated to a treatment or control group within 72 h following a tick bite and had no clinical evidence of Lyme disease at enrolment. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines were followed for data abstraction. Two authors (GZZ and XX) independently reviewed the abstracts and identified articles for detailed assessment. We used a random-effects model to calculate the pooled results and reported the 95% confidence interval (CI). Study quality was assessed using a modified Jadad scale, and publication bias was assessed using Egger’s test. We calculated the risk ratio (RR) for the rates of unfavorable events in patients who received intervention versus the control group. This study is registered with PROSPERO, number CRD42021245002. Results Six studies (3,766 individuals) were included. The pooled rate of unfavorable events in persons receiving treatment and the control group were 0.4% (95%CI: 0.1–1.1%) and 2.2% (95%CI: 1.6–3.0%), respectively. The pooled RR was 0.38 (95%CI: 0.22–0.66). Subgroup analysis revealed that the pooled RR was 0.29 (95%CI: 0.14–0.60) in the single-use 200-mg doxycycline group; 0.28 (95%CI: 0.05–1.67) in a 10-day course group (Amoxicillin, Penicillin or tetracycline); and 0.73 (95%CI: 0.25–2.08) in a topical antibiotic treatment group (Azithromycin). Conclusions The available evidence supports the use of antibiotics for the prevention of Lyme disease, and reveals advantages of using single-dose; however, further confirmation is needed.Guozhong ZhouXin XuYu ZhangPeng YueShiqi LuoYuxin FanJingjing ChenMeixiao LiuYan DongBingxue LiJing KongShiyuan WenAihua LiuFukai BaoBMCarticleBorrelia burgdorferiBorreliosisIxodesLyme diseaseTick biteInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Borrelia burgdorferi Borreliosis Ixodes Lyme disease Tick bite Infectious and parasitic diseases RC109-216
spellingShingle	Borrelia burgdorferi Borreliosis Ixodes Lyme disease Tick bite Infectious and parasitic diseases RC109-216 Guozhong Zhou Xin Xu Yu Zhang Peng Yue Shiqi Luo Yuxin Fan Jingjing Chen Meixiao Liu Yan Dong Bingxue Li Jing Kong Shiyuan Wen Aihua Liu Fukai Bao Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis
description	Abstract Background In areas where Lyme disease is endemic, bites from ticks are common, but no vaccine is currently available against Lyme disease for humans. Therefore, the feasibility of using antibiotic prophylaxis to prevent Lyme disease after a tick bite is worth further exploration. Previous meta-analyses lack sufficient power to demonstrate the efficacy of about antibiotic prophylaxis for the prevention of Lyme disease following a tick bite. In this study, we explored more precise evidence and attempted to identify and update optimum treatment strategies. Methods We searched PubMed, Embase, and the Cochrane Library for studies until March 23, 2021. We included studies if the enrolled patients were randomly allocated to a treatment or control group within 72 h following a tick bite and had no clinical evidence of Lyme disease at enrolment. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines were followed for data abstraction. Two authors (GZZ and XX) independently reviewed the abstracts and identified articles for detailed assessment. We used a random-effects model to calculate the pooled results and reported the 95% confidence interval (CI). Study quality was assessed using a modified Jadad scale, and publication bias was assessed using Egger’s test. We calculated the risk ratio (RR) for the rates of unfavorable events in patients who received intervention versus the control group. This study is registered with PROSPERO, number CRD42021245002. Results Six studies (3,766 individuals) were included. The pooled rate of unfavorable events in persons receiving treatment and the control group were 0.4% (95%CI: 0.1–1.1%) and 2.2% (95%CI: 1.6–3.0%), respectively. The pooled RR was 0.38 (95%CI: 0.22–0.66). Subgroup analysis revealed that the pooled RR was 0.29 (95%CI: 0.14–0.60) in the single-use 200-mg doxycycline group; 0.28 (95%CI: 0.05–1.67) in a 10-day course group (Amoxicillin, Penicillin or tetracycline); and 0.73 (95%CI: 0.25–2.08) in a topical antibiotic treatment group (Azithromycin). Conclusions The available evidence supports the use of antibiotics for the prevention of Lyme disease, and reveals advantages of using single-dose; however, further confirmation is needed.
format	article
author	Guozhong Zhou Xin Xu Yu Zhang Peng Yue Shiqi Luo Yuxin Fan Jingjing Chen Meixiao Liu Yan Dong Bingxue Li Jing Kong Shiyuan Wen Aihua Liu Fukai Bao
author_facet	Guozhong Zhou Xin Xu Yu Zhang Peng Yue Shiqi Luo Yuxin Fan Jingjing Chen Meixiao Liu Yan Dong Bingxue Li Jing Kong Shiyuan Wen Aihua Liu Fukai Bao
author_sort	Guozhong Zhou
title	Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis
title_short	Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis
title_full	Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis
title_fullStr	Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis
title_full_unstemmed	Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis
title_sort	antibiotic prophylaxis for prevention against lyme disease following tick bite: an updated systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/280ec6ec224e4649bedfbd65b99d17bc
work_keys_str_mv	AT guozhongzhou antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT xinxu antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT yuzhang antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT pengyue antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT shiqiluo antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT yuxinfan antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT jingjingchen antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT meixiaoliu antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT yandong antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT bingxueli antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT jingkong antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT shiyuanwen antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT aihualiu antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis AT fukaibao antibioticprophylaxisforpreventionagainstlymediseasefollowingtickbiteanupdatedsystematicreviewandmetaanalysis
_version_	1718429035758878720

Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

Ejemplares similares