Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis

Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis

Glucocorticoids (GCs) inhibit bone angiogenesis and affect bone development, but the underlying mechanisms remain unclear. Here, the authors show that GCs induce vascular cell senescence during bone development by inhibiting angiogenin secretion from osteoclasts, impairing angiogenesis via endotheli...

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Autores principales: Xiaonan Liu, Yu Chai, Guanqiao Liu, Weiping Su, Qiaoyue Guo, Xiao Lv, Peisong Gao, Bin Yu, Gerardo Ferbeyre, Xu Cao, Mei Wan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2813a0eb6f044c13837b00ae72f5f57e
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spelling oai:doaj.org-article:2813a0eb6f044c13837b00ae72f5f57e2021-12-02T11:44:56ZOsteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis10.1038/s41467-021-22131-12041-1723https://doaj.org/article/2813a0eb6f044c13837b00ae72f5f57e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22131-1https://doaj.org/toc/2041-1723Glucocorticoids (GCs) inhibit bone angiogenesis and affect bone development, but the underlying mechanisms remain unclear. Here, the authors show that GCs induce vascular cell senescence during bone development by inhibiting angiogenin secretion from osteoclasts, impairing angiogenesis via endothelial Plexin B2, resulting in unpaired bone growth.Xiaonan LiuYu ChaiGuanqiao LiuWeiping SuQiaoyue GuoXiao LvPeisong GaoBin YuGerardo FerbeyreXu CaoMei WanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaonan Liu
Yu Chai
Guanqiao Liu
Weiping Su
Qiaoyue Guo
Xiao Lv
Peisong Gao
Bin Yu
Gerardo Ferbeyre
Xu Cao
Mei Wan
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
description Glucocorticoids (GCs) inhibit bone angiogenesis and affect bone development, but the underlying mechanisms remain unclear. Here, the authors show that GCs induce vascular cell senescence during bone development by inhibiting angiogenin secretion from osteoclasts, impairing angiogenesis via endothelial Plexin B2, resulting in unpaired bone growth.
format article
author Xiaonan Liu
Yu Chai
Guanqiao Liu
Weiping Su
Qiaoyue Guo
Xiao Lv
Peisong Gao
Bin Yu
Gerardo Ferbeyre
Xu Cao
Mei Wan
author_facet Xiaonan Liu
Yu Chai
Guanqiao Liu
Weiping Su
Qiaoyue Guo
Xiao Lv
Peisong Gao
Bin Yu
Gerardo Ferbeyre
Xu Cao
Mei Wan
author_sort Xiaonan Liu
title Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
title_short Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
title_full Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
title_fullStr Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
title_full_unstemmed Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
title_sort osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-b2 axis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2813a0eb6f044c13837b00ae72f5f57e
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AT weipingsu osteoclastsprotectbonebloodvesselsagainstsenescencethroughtheangiogeninplexinb2axis
AT qiaoyueguo osteoclastsprotectbonebloodvesselsagainstsenescencethroughtheangiogeninplexinb2axis
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